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The pharmaceutical sciences are advancing rapidly in the post-genomic era of the 21st century with the completion of the human genome, as well as those of many other organisms including bacteria and parasites, and the rapid advances in proteomics.
      
Aqueous and organic solvent extracts tested by agar-well diffusion method against 12 human pathogenic bacteria and 3 fungal strains showed activity to most of the organisms.
      
These findings provide compelling evidence that DNA is the ultimate target of these drugs that act on the human genome.
      
The pharmacokinetics of α- and β-diastereomers of Arteether, a well-known antimalarial drug and its active metabolite dihydroartemisinin (DHA) were studied in Sprague-Dawley rats, Rhesus monkeys and human volunteers.
      
STUDIES ON NOVEL NON-IMIDAZOLE HUMAN H4 RECEPTOR ANTAGONISTS USING GFA AND FREE-WILSON ANALYSIS
      
5-Aza analogs were prepared of several tryptamine derivatives and a skatole derivative known to bind at human 5-HT6 receptors and evaluated to determine if they bind in a manner similar to their indolic analogs.
      
Most of the compounds increase the cAMP content of CHO cells expressing the human A1-adenosine receptor, indicating an antagonist activity.
      
Inhibitive Effect of Prodigiosin on the Proliferation of Human Malignant Pancreatic Cancer Cells
      
In this study, we find that prodigiosin could effectively inhibit the proliferation of human pancreatic cancer cells H8898 in a dose-and-time-dependent manner, with an IC50 of 75μmol according to the results of MTT and cell proliferation assays.
      
Among the nine compounds tested, 5h showed the best selective antiproliferative properties in vitro, being especially active against the human metastatic melanoma cells - inhibition by 93% after 96 h treatment at 10-4 M concentration.
      
32% or less, have been evaluated in a full panel of 60 human cancer cell lines over a 5-log dose range at the National Cancer Institute.
      
Human immunodeficiency virus type 1 (HIV-1) integrase is a potential target for anti-HIV therapy.
      
Efavirenz is a trifluoromethylated inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) that shows good results in anti-HIV chemotherapy.
      
These derivatives exhibited in vitro stability in buffers of pH 2.0 and 7.4 for 6 h and were readily hydrolyzed by human plasma esterases to liberate the parent drug.
      
Anilines 6a, b, d, and h demonstrated nonselective inhibition of COX-1 and -2 in human whole blood.
      
Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell pr
      
Effects of garlic and black grape extracts on the activity of adenosine deaminase from cancerous and noncancerous human urinary
      
All newly synthesized compounds were evaluated for their antiproliferative activities against human lung tumor cell lines (A 549).
      
According to the protocol of the National Cancer Institute (NCI) in vitro disease-oriented human cells screening panel assay, 13 compounds showed promising broad spectrum antitumor activity.
      
When it is used to combine several pieces of uncertain information, the scheme deserves the following merits: (1) It is consistent with human intuition; (2) No exact point-valued probability is required.
      
 

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