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Excessive accumulation of intracellular sorbitol found in various tissues of diabetic animals and in cells cultured under high glucose conditions has been proposed to be an important factor for the pathogenesis of diabetic complications.
      
The biological activity on cancer cells and the pharmacokinetics have also been evaluated, showing a very high liver-to-skin ratio and short retention time in tissues.
      
Aldose reductase inhibitors have been found to prevent sorbitol accumulation in tissues.
      
In this article, a method for quantitative determination of phytochelatins (PCn being the classic example) and other thiol-containing compounds in mixed standard solution and plant tissues is presented.
      
The direction of transient expression of GUS and GFP in Agrobacterium mediated 3-4 days transformed leaf discs of Populus tomentosa, indicating that the promoter did have bidirectional transcriptional activities simultaneously in cells and tissues.
      
Expression of hSef in various human tissues and cell lines
      
To determine the correlation of Sef with human diseases, Sef expression patterns were observed in cell lines and human cancer tissues.
      
Immunohistochemical analysis revealed a high expression level of hSef in kidney, testis, and the corresponding carcinoma tissues.
      
Results demonstrated that Sef might be up-regulated in the cancer tissues suggesting a possible role of Sef in pathophysiology of human diseases.
      
Differences on Pb accumulation among plant tissues of 25 varieties of maize (Zea mays)
      
Northern blot result shows that the gene is expressed in all examined adult tissues.
      
In this paper we report several 3D-preserved rare star-like fossils with finely preserved soft tissues which were recovered from the Kuanchuanpu Member of the Dengying Formation in South Shaanxi, China in 2003.
      
LOH and MSI of the FHIT were detected by using PCR at 4 microsatellite loci: D3S 1300, D3S 4103, D3S 1481, D3S 1234 in cancer tissues from 50 patients with primary GC, with normal mucosa acting as matched controls.
      
Aberrant transcripts were found in 11/30 GC tissues.
      
Four of 10 (40.0%) cases of primary GC showed absent or decreased expression of the FHIT protein as compared to their matched normal tissues.
      
The morphologic changes in pancreatic tissues were observed.
      
The fragile histidine triad (FHIT) gene, a candidate tumor suppressor gene located at 3p14.2, has been shown to be involved in the carcinogenesis of many human tissues, including digestive tract tissues.
      
It was found that the phenotype of the culture-expanded pluripotent stem cells from different fetal tissues was similar to BM-derived Flk1+CD34- PPSCs, i.e.
      
More importantly, culture-expanded pluripotent stem cells from all these fetal tissues were able to differentiate into cells with morphologic and phenotypic characteristics of adipocytes, osteocytes, neurons, glial cells and hepatocytes.
      
These pluripotent stem cells with characteristics similar to fetal BM-derived Flk1+CD34- PPSCs can be selected and cultured from tissues other than the BM.
      
 

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