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Overall the pharmacokinetic properties of both isomers were similar in rats, monkeys and humans, with β-isomer exhibiting longer elimination half-life, MRT, volume of distribution and clearance, irrespective of the route of administration.
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5-FU-PT was given to rats by oral administration at a dosage of 22.5?mg kg-1.
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In some organs (apart from kidneys, intestinal system, and stomach) the uptake of 99mTc-AA was not significantly affected by the administration of 99mTc with CPR or 99mTc with APAP at 120?min.
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The administration of 99mTc-AA with PPA in rats caused an increase of the uptake of 99mTc-AA at 120?min in the investigated organs compared to the administration of 99mTc-AA alone.
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From these data, it may be deduced that the administration of high concentration of 18-methyl norethindrone can displace ketoprofen from its secondary binding site.
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Specific immune response to this recombinant strain was evaluated by oral administration of the recombinant live bacteria pBO1/S.
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Alleviation of cell damage in experimental ANP in rats by administration of chondroitin-sulfate reduces
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Vestibular function was tested at 21:00 on the first day and 1, 3, 5, 7 h after drug administration.
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Three weeks after drug administration, pAT1a-shRNA1, pAT1a-shRNA2 and valsartan respectively resulted in decrease of the tail blood pressure by (15.1 ± 5.4), (16.4 ± 8.4) and (30.6 ± 18.2) mmHg.
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Architecture design of Exit-Entry Administration Building of Shanghai Municipal Public Security Bureau
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combined administration of high-and lowmolecular-weight microbial autoregulators (extracellular RNase fromBacillus intermedius and anabiosis inducing factord1) are reported for the first time for cultured cells of higher eukaryotes.
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Studies of the effects of combined administration of the autoregulators demonstrated that pretreatment of the cells with low-dosed1 decreased the toxicity of RNase.
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Changes in trypsin inhibitor activity, lectin activity, and the content of endogenous salicylic acid after administration of exogenous salicylic acid or a pathogen were shown to depend on the resistance of maize strains to Fusarium.
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Administration of the preparations involving the selected bifidobacteria and lactic acid bacteria assisted in the normalization of the intestinal microflora and activation of protein metabolism in the organism of animals.
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Experiments on animals showed that native proteins may diffuse into the blood flow after oral administration of diluted protein solutions.
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The administration of the exogenous NO donor, dinitrosyl iron complexes (DNIC), limited the behavioral disturbances induced by L-DOPA in both rat strains.
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DSIP and most analogs had no statistically significant effect on sleep compared to the control administration of saline to the same animals.
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The effects of these two extracts were tested on rats using the open field and passive avoidance tests upon intranasal administration of the extracts (ca.
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We studied hemocoagulant properties of the amino acid glycinein vitroand after intravenous administration to animals (rats).
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Intravenous administration of glycine increased the functional activity of the enzymatic fibrinolytic unit of the anticoagulation system.
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