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Aminochalcone 18, which has an IC50 value of 0.24 μM, was the most potent compound.
      
In vitro enzyme inhibition studies have identified three inhibitors (14, 16, 23) of the falcipains with one (14) showing dual activity against both falcipain-2 and falcipain-3 and IC50 values of 6.6 and 29.4 μM, respectively.
      
In this study, we find that prodigiosin could effectively inhibit the proliferation of human pancreatic cancer cells H8898 in a dose-and-time-dependent manner, with an IC50 of 75μmol according to the results of MTT and cell proliferation assays.
      
Additionally, (2) also inhibited the proliferation of human erythroleukemia cancer cell line K562 with IC50 value of 49.1 μg/mL.
      
1 exhibited significant inhibitory activity against the human DNA topoisomerase I (hTopo I), the cancer cell lines BEL-7402 and MCG-803, with the IC50 values 12.0, 6.5, and 8.0 μg/mL, respectively.
      
An improved ion chromatographic (IC) method was developed to determine trace levels of perchlorate in environmental water samples.
      
Physical defects have always played an important role in integrated circuit (IC) yields, and the design sensitivity to these physical elements has continued to increase in today's nanometer technologies.
      
In addition, among 41 inhibited IC neurons, 90.2% (37/41) exhibited narrowed dynamic range (DR) when masker sound duration was increased (P >amp;lt; 0.000 1), whereas the DR of 9.8%(4/41) became wider.
      
These data suggest that masking effects of different durations of forward masker sound might be correlated with the amplitude and duration of inhibitory input to IC neurons elicited by the masker sound.
      
For those patients with acute or total occlusion, the levels of myocardial perfusion before and after PCI were similar, as determined by IC-MCE and visually analyzed from 61 segments (P >amp;lt; 0.05).
      
Quantitative IC-MCE evaluation of myocardial reperfusion is more accurate than with the other two methods.
      
Moreover, with qualitative IC-MCE the level of myocardial reperfusion can be viewed directly and rapidly.
      
Thus, the IC-MCE method is of great value to coronary artery disease (CAD) patients undergoing PCI, especially for those with acute myocardial infarction (AMI).
      
The half-effect concentrations (IC50) based on the seed germination and root elongation of the test crops exposed to the wastewater discharged from various processing phases of MSG production was 22.0-32 432 and 17.3-3320 mg/L, respectively.
      
In this paper, an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) was established and used to detect microcystin-LR (MC-LR) in drinking and surface waters.
      
NDGA inhibited the enzyme in vitro(IC50=142 μM), but its addition in the exponential phase of growth activated the enzyme.
      
These extracts also showed an inhibitory effect on xanthine oxidase activity, but with a lesser potency (IC50 is 9.17 μg/ml for AM-H2O and 7.48 μg/ml for AM-EtOH).
      
Interestingly, the antilipid peroxidation activity of AM-H2O (IC50-6.66 μg/ml) in brain homogenate was as good as IC50-5.42 μg/ml.
      
The dose-inhibitory effect curves for Livagen and Epitalon were plotted; their IC50 equaled 20 and 500 μM, respectively.
      
All compounds used inhibited ADP-induced aggregation of human platelets with IC50 of 10.0, 1.3, and 2.0 μM for 5-nitro-, 7-nitro-, and 5,7-dinitrobenzotetrazine-1,3-dioxides, respectively.
      
 

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