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Seven compounds caused 50% growth inhibition (GI50) of tumor cells at concentrations of >amp;lt;100 μM while the remaining ten were not cytotoxic.
      
With regard to sensitivity, compounds 8f and 9c, f have proved to possess a remarkable activity against leukemia tumor cell lines (GI50?=?3.43-5.03?μM).
      
All newly synthesized compounds were evaluated for their antiproliferative activities against human lung tumor cell lines (A 549).
      
Analysis for a free boundary problem modeling tumor therapy
      
Tumor necrosis factor (TNF)-α-converting enzyme (TACE) is the major protease responsible for processing pro-TNF-α from membrane-anchored precursors to secreted TNF-α.
      
Some of them have anti-microbial effects, counteract inflammation, and inhibit tumor progression activities.
      
Cloning and biological activity of an anti-tumor peptide of Tumstatin
      
To obtain an anti-tumor peptide of Tumstatin and detect its biological activity, the nucleotide sequence encoding 185-203 amino acids (19peptide) of Tumstatin was synthesized and inserted into the fusion protein vector pTYB2.
      
The tumor inhibition rate of mice ascitic fluid transfevent H22 hepatoma was 48.46%.
      
Histopathological slices showed that it could promote tumor tissue necrosis and decrease the density of blood vessels.
      
With higher anti-tumor activity, 19peptide has the potential to become a novel, potent anti-tumor agent.
      
And KIAA0372 is thought to be a potential target for tumor research using bioinformatic analysis.
      
Developing effective tumor vaccines: basis, challenges and perspectives
      
A remarkable advance in tumor immunology during the last decade is the elucidation of the antigenic basis of tumor recognition and destruction.
      
A variety of tumor antigens have been identified using several strategies including conventional experiments and newly developed bioinformatics.
      
Successful immunotherapy of tumors requires understanding of the natural relationship between the immune system and tumor in the status of differentiation, invasion and maturation.
      
The 5-year tumor-free survival rates for the group I, group II and group III were 34.1%, 36.1% and 37.8%, respectively.
      
Functional cytokines can enhance dendritic cell anti-tumor immune responses.
      
DCs were pulsed with tumor cell lysate after being modified wth IL-23.
      
Results showed inhibitory effects on tumor cells and increased survival time in the experimental group treated with the vaccine combined with β-elemene.
      
 

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