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Calderón-Zygmund singular integral operators have been extensively studied for almost half a century.
      
Drug Development in the 21st Century: Medicines, Man and Receptors
      
THE SHAPE OF MEDICINES TO COME: PHARMACEUTICALS IN THE 21ST CENTURY
      
The pharmaceutical sciences are advancing rapidly in the post-genomic era of the 21st century with the completion of the human genome, as well as those of many other organisms including bacteria and parasites, and the rapid advances in proteomics.
      
Pancreatic cancer is not only common, but also extremely difficult to treat, for which it has been called "the challenge of the twenty-first century".
      
Digital manufacturing-the development direction of the manufacturing technology in the 21st century
      
As the core of the advanced manufacturing technology, digital manufacturing is gradually becoming the main manufacturing technology of the twenty-first century.
      
The broad sense of manufacturing theory, which extends the concept of manufacturing, is an important development in the 20th century.
      
The utilization of vibration and wave, which was developed during the latter half of the 20th century, is one of the most valueable technology applications and has been rapidly developing recently [1-10].
      
In this century, China started facing five major challenges in the energy field: energy supply, shortage of liquid fuel, environmental pollution, green house gas (GHG) emission, and energy supply in rural areas.
      
At the end of last century, stem cells were found in the brain of the adult mouse and rat and later in the brain of other mammals including humans.
      
Outstanding Biologist of 20th Century (on the 75th Anniversary of the Birth of Academician V.E.
      
History of Marine Microbiology in Russia (the Soviet Union) in the Second Half of the 20th Century
      
Gilyarov's scientific school in the development of the subject and methodology of a new complex discipline formed in the mid 20th century-soil zoology-was considered.
      
One of the last destabilizations occurred in the first half of the 20th century when the southern limit of the breeding range receded northward by 100-300 km.
      
The development of stable isotope techniques is one of the main methodological advances in ecology of the last decades of the 20th century.
      
A considerable amount of data confirming this hypothesis was accumulated during the last quarter of the last century.
      
The atomic structures of photosynthetic reaction centers of two species of purple bacteria and two photosystems 2 of cyanobacteria were resolved in the late last century.
      
For a quarter of a century the gene p53 has attracted close attention of scientists who deal with problems of carcinogenesis and maintenance of genetic stability.
      
Among of the highlights of the 20th century were flights of spacecraft to other bodies of the Solar System.
      
 

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