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Guanidine-type compounds that reached clinical status include amongst others the potassium channel opener, pinacidil and the histamine H2-receptor antagonists (e.g.
      
(ii) Other compounds have proceeded through preclinical and/or clinical development: CXCR4 antagonists (i.e.
      
(iii) Yet other compounds, acting by novel mechanisms, have recently been identified as anti-HIV agents that seem worthy of further (pre)clinical development: cell receptor CD4 downmodulators (i.e.
      
PRE-CLINICAL AND CLINICAL PHARMACOKINETICS OF THE DIASTEREOMERS OF ARTEETHER, A POTENT ANTIMALARIAL
      
Pre-clinical studies were carried out (N=3) by oral, intramuscular and intravenous routes, while clinical studies (N=13) were performed intramuscularly.
      
Multiple-drug therapy is common in current clinical practice.
      
All agents are cytotoxic nitrogen mustard agents, a class of drugs widely used in the clinical treatment of cancer.
      
The use of in silico assisted drug design and multivariate analysis of these compounds discerned discrete interrelationships and information for evaluating potential clinical application.
      
Therefore, it is a very important subject in clinical practice to measure and classify the ECG ST segment.
      
Clinical analysis of 275 cases of acute drug-induced liver disease
      
Each was determined by drug history, clinical symptoms and signs, laboratory tests and therapeutic effects.
      
The principal clinical manifestation included nausea (54.8%), fatigue (50.2%), jaundice (35.6%).
      
The patients' medical records were reviewed and the clinical information was extracted.
      
They have become closer to the clinical practice, standardized and observable.
      
Splenic autotransplantation and oesophageal transection anastomosis in patients with portal hypertension (26 years clinical obse
      
In this study, we evaluated the effectiveness of a new treatment strategy: splenic auto-transplantation and oesophageal transection anastomosis on 274 patients from three aspects: clinical observation, splenic immunology and portal dynamics.
      
From 1979 to 2005, 274 cirrhosis patients with portal hypertension who underwent the new treatment strategy were followed up to observe different clinical indexes, which were then compared with those of the traditional surgery treatment.
      
The dendritic cell vaccine is a treatment vaccine with potent clinical applications.
      
Based on continuously solidifying theories and clinical practice, many advanced concepts with applicable clinical frameworks have been established, thus making splenic surgery an indispensable division in modern surgery.
      
Now, standard grading for splenic injury and the respective guidelines for clinical management have been established, with the use of selective instead of indiscriminate splenectomy being accepted by most experts.
      
 

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