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apoptotic rate
Over-expression of FHIT is directly proportional to the apoptotic rate in the tumors examined.
      
However, GLM cells differ from conventional gastric cancer cell lines in their high apoptotic rate, even in the absence of apoptosis inducing stimuli as revealed by Caspase3/7 assay and the TUNEL method.
      
29.9% ±1.1% in controls, mean ± SEM, P >amp;lt; 0.007) and an increased apoptotic rate (14.5 ± 1.1 apoptotic cells/mm2 vs.
      
Treatment of B16a cells in vitro with PAC-1 significantly inhibited proliferation by decreasing the mitotic index but not affecting apoptotic rate.
      
Highest apoptotic rate was observed in medium with pH 7.2, whereas it was partially and completely inhibited at pH 6.5 and pH 6.0, respectively.
      
The apoptotic rate of cervical carcinoma cells in response to cisplatin was increased if their cellular cytokeratin-19 level was reduced by specific antibody MAb Cx-99.
      
In our previous study on fixed tissue blocks, we reported a high apoptotic rate in patients with operated small cell lung carcinomas.
      
When cells were irradiated under an extremely hypoxic condition, the apoptotic rate was strongly suppressed.
      
The MAPK inhibitors revealed that the apoptotic rate in LNCaP cells increased significantly following p38 inhibition.
      
Embryo proteins induced a significant reduction in FLIP levels, and increased caspase-3 and caspase-8 activity as well as the apoptotic rate.
      
The TUNEL staining revealed that tumor cells in cPrG·HCl plus epirubicin-treated mice exhibited a higher apoptotic rate.
      
Untreated CD exhibited a trend toward a superior accumulation of IFN-γ per cell but a reduced proportion of INF-γ+ cells in vitro in association with a significantly increased apoptotic rate of IELs.
      
ACE-I also dramatically reduced the epithelial apoptotic rate.
      
HepG2 cells transfected with the antisense hTR gene showed down-regulated telomerase activity, inhibited cell growth, decreased PCNA expression, and increased apoptotic rate.
      
Moreover, sorted CD4+CD45RO+and CD4+CD45RO+ CD28null T cells from patients with active CD exhibited a lower apoptotic rate than that found in healthy controls and inactive CD patients.
      
In the present study, we investigated the morphological myelodysplasia and apoptotic rate of bone marrow cells in 15 patients with BD in comparison with MDS patients.
      
The apoptotic rate in BD patients (26.1?±?8.4%) was significantly higher in normal controls (11.3?±?2.4%; p?>amp;lt;?0.005) and significantly lower in patients with MDS (50.8?±?14.0%; p?>amp;lt;?0.0001).
      
Pretreatment with the A3 adenosine receptor agonist N6-(3-iodobenzyl) adenosine-5'-N-methyluronamide (IB-MECA, 0.1 μM), led to a partial decrease in apoptotic rate induced by Ang II.
      
In this study we assessed the proliferation rate by measuring the Ki-67 labelling index using the MIB-1 antibody (MIB-LI) and the apoptotic rate using the in situ labelling of DNA strand breaks with TUNEL (TUNEL-LI) in 315 supratentorial gliomas.
      
These results implicate apoptotic rate in meningioma growth and recurrence and denote that assessment of apoptotic potential by means of anti-ssDNA monoclonal antibody provides valid prognostic information irrespective of other parameters.
      
 

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