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downstream target gene
A major BRCA1 downstream target gene is the DNA damage-responsive gene GADD45.
      
The transgenic plants also showed an increased expression of AtP5CS2, which was confirmed to be a downstream target gene of DREB in Arabidopsis.
      
We evaluated whether the gap junction protein Connexin43 (Cx43), an important regulator of osteoblast function and bone development, may be a downstream target gene regulated by Tbx2.
      
Previously, we demonstrated that HDAC inhibitors, such as sodium butyrate and trichostatin A (TSA), transcriptionally induce the cyclin-dependent kinase inhibitor p21WAF1/Cip1, a downstream target gene of p53, in a p53-independent manner.
      
Furthermore, we have recently shown that HDAC inhibitors activate Gadd45, another downstream target gene of p53, and p19INK4d, a gene functionally similar to p16INK4a.
      
Also, at stage 4 there is a substantial increase in expression of NGN3 and its downstream target gene PAX4.
      
In summary, the reduced expression of the Notch1 downstream target gene Hes5 suggests a downregulation of Notch signalling in the absence of PS1.
      
Our rationale for searching for a mouse homolog of cerberus was that cerberus may be a downstream target gene of Lim1 in the head induction pathway.
      
Of particular interest is the marked upregulation of both wnt-1 and its downstream target gene WISP-2.
      
These findings identify vps33b as a novel downstream target gene of the hnf6/vhnf1 pathway that regulates bile duct development in zebrafish.
      
The results indicate that neural induction by the b-Catenin signal requires expression of its downstream target gene Chordin.
      
We assessed p53 activity by looking for increased levels of the p53 downstream target gene product, p21.
      
 

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