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Conclusion: The pathological findings in gastric gland accorded with the Houston diagnostic criteria of antrum-predominant CAG.
      
κ-λ populations of the matched serum, CSF and brain specimens were all λ-predominant and in agreement with each other; the light chain distribution of the brain specimens confirmed previous findings [3].
      
Atrophy of the cerebellum and brain stem an CT or MRI had suggested dominant spinocerebellar ataxia as a diagnosis in their ataxia-predominant stage, with a diagnosis of DRPLA being impossible based on the clinical findings alone.
      
Such factors include increased sensitivity of dopamine receptors and alteration of synaptic transmission (plasticity) or the striosome-predominant pattern of information processing in the striatum.
      
A diagnosis of prediabetes should be sought in patients with otherwise idiopathic sensory-predominant neuropathy by doing a 2-hour oral glucose tolerance test.
      
Although only two medications, tegaserod for constipation-predominant IBS and alosetron for diarrhea-predominant IBS, are specifically indicated, a wide variety of treatment options are available and are discussed in this review.
      
5-HT3 antagonists reduce bowel frequency and pain in women with diarrhea-predominant IBS, but their use is limited because of ischemic colitis.
      
Lymphocyte-predominant Hodgkin's lymphoma (LPHL) differs in histologic and clinical presentation from classical Hodgkin's lymphoma (cHL).
      
The hallmark of bacterial vaginosis is the shift in the microbiology of the vaginal flora away from a lactobacilli-predominant milieu.
      
Bacterial vaginosis, the most prevalent cause of vaginal discharge in the United States, is characterized microbiologically by a shift in the vagina away from a lactobacillus-predominant flora and toward a predominantly anaerobic milieu.
      
Rituximab for lymphocyte-predominant Hodgkin's disease
      
The diagnostic criteria suggest that meal-related and pain-predominant symptom groupings that presumably have distinct pathophysiologic mechanisms and potentially different therapeutic targets exist.
      
The best example of this is the finding that methanogenic organisms in IBS patients are wholly associated with constipation-predominant IBS.
      
Diarrhea- and constipation-predominant irritable bowel syndrome
      
5-HT3 antagonists such as alosetron improve urgency, stool consistency, and pain in diarrhea-predominant-IBS.
      
The 5-HT4 agonist tegaserod shows modest benefit in constipation-predominant IBS, improving stool frequency, consistency, and bloating as well as global improvement.
      
For constipation-predominant (C-IBS) symptoms, current treatment options include fiber supplementation, polyethylene glycol, and tegaserod.
      
For diarrhea-predominant (D-IBS) symptoms, available therapies include loperamide, alosetron, and clonidine.
      
First, FD needs to be distinguished from diarrhea-predominant irritable bowel syndrome (IBS), in which, unlike in FD, abdominal pain is a primary diagnostic criterion.
      
The diagnostic criteria suggest that meal-related and pain-predominant symptom groupings that presumably have distinct pathophysiologic mechanisms and potentially different therapeutic targets exist.
      
 

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