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rb gene
The retinoblastoma (Rb) gene probe p123 M1.8 and p68 Rs2.0 were used to study the frequencies of theBamHI andRsaI restriction fragment length polymorphisms (RFLPs) in the Rb gene among the population of Han nationality in Guangdong Province.
      
Conclusion: p16, Cyclin D1 and Rb gene play important role in gastric carcinoma genesis.
      
The expression of p16, cyclin D1 and Rb gene have some value to the diagnosis at earlier stage of gastric cancer.
      
Detection of loss of heterozygosity in the RB gene in the patients with gastric carcinoma with PCR-VNTR
      
Objective: Detection of loss of heterozygosity (LOH) of RB gene in patients with gastric carcinoma with PCR-VNTR.
      
Conclusion: PCR-VNTR was a simple and rapid technique for the detection of LOH of RB gene in patients with gastric carcinoma, and it might be useful in the earlier diagnosis of gastric carcinoma.
      
Our findings indicated that 1) the RB gene is located at 13q14.1.
      
We have previously found Rb gene mutations in 55% of malignant thyroid tumors.
      
Six of them were found in carcinomas without Rb gene mutations.
      
Among the remaining 15 thyroid carcinoma samples, 11 were found previously to have Rb gene mutations.
      
Two mechanisms may be involved in the inactivation of pRb: one is through Rb gene mutations, and the other is by cyclin D1 overexpression.
      
Molecular analyses of the tumor specimens confirmed loss of heterozygocity of the Rb gene region.
      
Our assay utilizes two approaches toward primer design, allowing discrimination between the RB transgene and both the endogenous RB gene and numerous RB homeologs.
      
Genomic DNAs were used as templates in polymerase chain reaction (PCR) with primers selected to amplify exons 2 to 20 of the human Ob-Rb gene.
      
The present study represents the first report of sequence variants of the Ob-Rb gene in the Japanese and provides evidence against either obesity-causing mutations or association of sequence variants with obesity in obese Japanese subjects.
      
In the present study, primary and secondary glioblastomas were analyzed for p16 deletions and CDK4 amplification by differential PCR and for loss of expression of the retinoblastoma (RB) gene by immunohistochemistry.
      
Our results suggest that Rb gene deregulation does not significantly affect prognosis but p21 expression may play an important role in disease-free survival of astrocytoma patients.
      
An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma
      
Mutation of the K-ras oncogene, and disruption of p53 or p16 tumour suppressor gene abrogates the control of the cyclin-dependent kinases (cdk) and retinoblastoma (Rb) gene pathway, causing continuous growth of the pancreatic tumour.
      
Loss of RB protein expression was seen in two MPNSTs (17%), and LOH of the Rb gene was detected in four tumors (44%), including the two NF1-associated MPNSTs, one of them showing concomitant loss of RB protein expression.
      
 

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