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carcinoma tissues
Immunohistochemical analysis revealed a high expression level of hSef in kidney, testis, and the corresponding carcinoma tissues.
      
Western blot analysis showed HCR2 to be notably depressed in carcinoma tissues in 3 out of 4 HCC patients.
      
The aim of the present study was to investigate the genetic instability in cervical carcinoma tissues and provide evidence for discovering new tumor suppressor genes and screening diagnostic molecular marker of cervical carcinoma.
      
Methods: cDNA probes were prepared by labeling mRNA from samples of four pancreatic carcinoma tissues with Cy5-dUTP and mRNA from adjacent normal tissues with Cy3-dUTP respectively through reverse transcription.
      
Relationship among COX-2 protein expression, PGs levels and biologic behavior in ovarian carcinoma tissues
      
Objective: To study the relationship among cyclooxygenase-2 (COX-2) protein expression, prostaglandins levels and biologic behavior in ovarian carcinoma tissues.
      
The expression of COX-2 protein and its relative content showed no significant differences in ovarian carcinoma tissues of different clinical stages (I to II and III to IV), different histological grades, with or without ascites and lymph metastasis.
      
The levels of PGE2, 6-keto-PGF1α and TXB2 in ovarian serous carcinoma tissues were statistically higher than in borderline ovarian serous tumor, benign ovarian serous tumor or normal ovarian tissues (P>amp;lt;0.05).
      
The levels of PGE2, 6-keto-PGF1α and TXB2 showed no significant differences in ovarian carcinoma tissues with different clinical stages (I to II and III to IV), different histological grades, with or without ascites and lymph metastasis.
      
Expression and clinical significance of p73A in breast carcinoma tissues
      
Methods: The expression of p73α was detected by immunohistochemistry in 41 breast carcinoma tissues, 13 benign breast tumor tissues and 8 normal tissues and 8 normal breast tissues, respectively.
      
Results: The positive expression of p73α was found in 20/41 (48.8%) of breast carcinoma tissues, 1/13 (7.7%) of benign breast tumor tissues.
      
The positive expression rate of p73α in breast carcinoma tissues was significantly higher than that in benign breast tumor tissues and normal breast tissues (P>amp;lt;0.05).
      
The expression intensity of p73α increased significantly in breast carcinoma tissues compared with benign breast tumor tissues and normal breast tissues (P>amp;lt;0.05).
      
Conclusion: These results suggest that there is an up-regulation of p73α expression in breast carcinoma tissues, which may be implicated in the tumorigenesis of breast carcinoma as a molecular alteration.
      
Expression of the EphA2 gene in esophageal carcinoma tissues
      
Methylation-specific PCR and semi-quantitative RT-PCR were used to study the promoter methylation and mRNA expression of the MGMT gene in laryngeal carcinoma tissues, tissues adjacent to the tumor and normal laryngeal tissues.
      
No expression of MGMT mRNA was detected in all hypermethylated laryngeal carcinoma tissues.
      
The expression of MGMT mRNA was detected in all unmethylated laryngeal carcinoma tissues, tissues adjacent to the tumors and normal tissues.
      
It suggests that MGMT gene promoter hypermethylation is associated with MGMT gene transcription loss in laryngeal carcinoma tissues and possibly plays an important role in carcinogenesis of laryngeal tissues.
      
 

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