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induction of differentiation
To investigate the antitumor activity of IL-12, the induction of differentiation of IL-12 was observed using erythroleukemia cells (FBL-3) as model.
      
Cytoskeleton-associated protein tyrosine phosphorylation involved in induction of differentiation in mouse melanoma cells
      
But in myeloid leukemia, the stopping of growth in mature cells by induction of differentiation bypasses the genetic changes that produce the malignant phenotype.
      
On the role of the low-affinity neurotrophin receptor p75LNTR in nerve growth factor induction of differentiation and AP 1 bindi
      
Techniques are described for the culture of murine embryonic stem cells in the absence of heterologous feeder cells and for the induction of differentiation programs.
      
This review summarizes recent studies that reveal the antitumor potential of PEDF based on its antiangiogenic properties and its newly discovered direct antitumor effects, which involve the induction of differentiation or apoptosis in tumor cells.
      
No induction of differentiation was observed with 5-fluorouracil (5-FU) in the absence or presence of SP.
      
The addition of SP in the fresh medium after the removal of VP-16, MXT, or MMC (0.5 h treatment) enhanced the induction of differentiation.
      
Lastly, with monoclonal antibody 49H.8, it has been found that reactivity of the lines is weak until induction of differentiation, after which highly significant increases of reactivity are seen.
      
Our findings suggest that low dose ARA-C may act both by induction of differentiation and/or inhibition of proliferation.
      
T-leukemia cell lines CCRF-CEM, HPB-ALL, JM and MOLT-4: Changes in isoenzyme profiles during induction of differentiation
      
Biochemical analysis has been used to monitor the induction of differentiation in cultured human T-leukemia cell lines (CCRF-CEM, HPB-ALL, JM and MOLT-4) by the phorbolester 12-O-tetradecanoylphorbol 13-acetate (TPA).
      
Among the compounds tested, dodecyl ethyleneglycophospholipid with a pyridinioethyl group was the most effective in induction of differentiation of both cell lines.
      
We have studied the effect of the purine analog 6-ethylmercaptopurine (e6MP) on the growth and induction of differentiation in both wild-type and HGPRT-deficient HL-60 cells.
      
This possibility was confirmed by the finding that hypoxanthine completely prevented the reduction of intracellular purine nucleotide levels, as well as the induction of differentiation and the inhibition of cellular growth, by these folate analogs.
      
The induction of differentiation is dependent on both the concentration of and the duration of exposure to HMBA.
      
The results suggest that induction of differentiation contributes to the antineoplastic efficacy of this novel cisplatin derivative.
      
In this study we report on the in vitro effects of new original piperazine derivatives of butyric acid on the induction of differentiation and the growth inhibition of human erythroleukemia K562 cells and myeloid leukemia HL60 cells.
      
Results: 5-AZA in combination with either vitamin D analog produced a greater growth inhibition and induction of differentiation than either agent alone.
      
Apart from modulation of tumor-cell drug sensitivity, induction of differentiation might be an alternative in the treatment of tumors resistant to cytotoxic drugs.
      
 

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