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3D-QSAR STUDIES ON SUBSTITUTED DIHYDROPYRIDINES FOR THEIR α1A-ADRENERGIC RECEPTOR BINDING AFFINITY
      
Both these models predicted binding affinity of internal and external test set compounds including the enantiomers of compound no.
      
For example, N1-(4-aminobenzenesulfonyl)-5-azaskatole (18; Ki = 41 nM) displayed an affinity comparable to N1-(4-aminobenzenesulfonyl)skatole.
      
All compounds were characterized by binding affinity determination for 5-HT2A and 5-HT2C subtypes and antagonistic activity for 5-HT2B receptor in rat stomach fundus.
      
None of the new compounds showed affinity for 5-HT2A and 5-HT2C subtypes, but some of them displayed antagonistic activity in rat stomach fundus at micromolar concentrations.
      
DNA binding affinity (ΔTm) of the tested compounds did not correlate with either their anti-P.
      
When tested on a wide battery of receptors, including 5HT2A(h), 5HT3(h), α1, α 2, β1, β2, H1, H2, opioids, D1(h), D2(h), 5HT uptake, and DOPA uptake, compound 9 showed submicromolar affinity only for α2 (Ki = 205 nM) and H1 (Ki = 311 nM).
      
Novel 5-substituted esters and homologous ester and amido derivatives of 4,5 dihydro-3,3-diethyl-2(3H)-furanone were synthesized and evaluated for anticonvulsant activity in rodents and for affinity to a site on the GABAA receptor complex ([3H]TBOB).
      
The results showed a great affinity for soft Ag+ and UO22+ ions and formed 1:2 or 1:3 stoichiometric complexes.
      
Using the osteoblast culture technique, we detected cell behaviors on the biomaterial in vitro by SEM, and the cell affinity of the composite was found to be higher than that of the PLA scaffold.
      
Affinity labeling coupled with matrix assistant laser desorption tandem time of flight mass spectrometry for quantitative proteo
      
A relative quantitative method for differential proteomics by cleavable isotope-coded affinity tag (cICAT) and matrix-assisted laser desorption/ionization tandem timeof-flight mass spectrometry (MALDI-TOF-MS) was established.
      
All of these show that huperzine E has high binding affinity with AchE.
      
Capillary electrophoresis as a tool for screening aptamer with high affinity and high specificity to ricin
      
The affinity constant KA of LPS with serum albumin, hemoglobin, chitosan and lysozyme was 2.36 × 107, 2.03 × 108, 7.58 × 106, 2.82 × 104 L·mol-1, respectively.
      
Moreover, the diversity of the antibody population was maintained with the affinity maturation and renewal of the antibody.
      
After Ni2+-NTA resin affinity chromatography, the purity of the recombinant T800/T1300 protein was more than 90%.
      
After colony screening, the bacterium was cultured and the product was purified with affinity chromatography.
      
The affinity of the recombinant human RI with double site mutation was examined for RNase A and its anti-oxidative effect.
      
Results indicated that there were not many changes in the affinity for RNase A detected when compared with the wild type of RI.
      
 

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