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hiv
In recent years, significant progress has been made towards the chemotherapy (and ?prophylaxis) of HIV infections.
      
This has brought the total of licensed anti-HIV drugs to nineteen.
      
(iii) Yet other compounds, acting by novel mechanisms, have recently been identified as anti-HIV agents that seem worthy of further (pre)clinical development: cell receptor CD4 downmodulators (i.e.
      
cyclotriazadisulfonamides), viral envelope gp120-binding agents such as plant lectins and glycopeptide antibiotics, HIV integrase inhibitors such as the pyranodipyrimidine V-165, and two new classes of compounds (i.e.
      
Taken together, it is obvious that in recent years both more diverse and more efficient approaches have become available for the treatment of HIV infections.
      
HIV is the most significant risk factor for many opportunistic infections like tuberculosis, hepatitis, bacterial infections etc.
      
Design, synthesis and anti-HIV activity of a series of 4,6-diaryl-2-aminopyrimidines are reported in this paper.
      
Two of the synthesized compounds proved to be effective in inhibiting HIV-1 replication at micromolar concentrations.
      
QSAR analysis of caffeoyl naphthalene sulfonamide derivatives as HIV-1 integrase inhibitors
      
Human immunodeficiency virus type 1 (HIV-1) integrase is a potential target for anti-HIV therapy.
      
Caffeoyl naphthalene sulfonamide derivatives act against HIV integrase and thus have the potential to become a part of an anti-HIV drug regimen.
      
Design, synthesis, and biological evaluation of new 3-hydroxy-2-oxo-3-trifluoromethylindole as potential HIV-1 reverse transcrip
      
Efavirenz is a trifluoromethylated inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) that shows good results in anti-HIV chemotherapy.
      
We have used molecular docking with HIV-1 RT as a tool to design putative non-nucleoside reverse transcriptase inhibitors (NNRTIs).
      
QSAR study on some arylsulfonamides as anti-HIV agents
      
In pursuit of better anti-HIV drugs, quantitative structure-activity relationship (QSAR) studies were performed on a series of aryl sulfonamide HIV protease inhibitors using Win CAChe 6.1.
      
The QSAR model indicates that the thermodynamic descriptors (heat of formation, log P, and molar refractivity) and steric descriptor (solvent assessable surface area) play an important role for the anti-HIV activity.
      
The results of the present study may be useful on the designing of more potent anti-HIV agents.
      
This work deals with the statement and the solution of problems of optimal control of the human immune system affected by a human immunodeficiency virus (HIV).
      
The results illustrate the possibilities for the use of mathematical methods in the problem of extending the life of HIV-infected patients.
      
 

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