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cardia adenocarcinoma
The main causes for this interest have been the increasing incidence of gastroesophageal reflux disease (GERD) and cardia adenocarcinoma.
      
Using comparative genomic hybridization (CGH) analysis, one recent study reported that the 14q chromosomal arm showed a significantly higher rate of deletion in esophageal than in cardia adenocarcinoma.
      
Objective: To determine the association between tooth loss and the risk of developing esophageal squamous cell carcinoma, gastric cardia adenocarcinoma, or gastric non-cardia adenocarcinoma in a prospective study.
      
Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women
      
Objective: The rising incidence and the strong male predominance among patients with esophageal and gastric cardia adenocarcinoma remain unexplained.
      
Background: For reasons yet unknown, the incidence of esophageal and gastric cardia adenocarcinoma is increasing rapidly and moderately, respectively.
      
Methods: A nationwide Swedish population-based case-control study including 189 and 262 esophageal and cardia adenocarcinoma cases, respectively, 167 esophageal squamous-cell carcinoma cases, and 820 controls.
      
Results: We found no statistically significant associations between two different measures of job strain and the three cancer types, except between one job strain measure and risk of cardia adenocarcinoma (OR: 2.2; 95% CI: 1.0-4.8).
      
There was a moderately strong association between having a covert coping style, compared to an overt, and risk of both esophageal (OR: 1.8; 95% CI: 1.2-2.8) and cardia adenocarcinoma (OR: 1.5; 95% CI: 1.0-2.3).
      
Additionally, 4 of 6 studies found significant associations with gastric cardia adenocarcinoma.
      
An alarm ing 4 of 6 studies found significant associations with gastric cardia adenocarcinoma.
      
Gastric cardia adenocarcinoma is a common cancer in China and is more prevalent in areas of high-risk of ESCC.
      
Genetic information on gastric cardia adenocarcinoma and its preneoplasias is sparse.
      
In addition, other studies also show that PCNA protein overexpression can be observed in the carcinogenesis of gastric cardia adenocarcinoma.
      
Risk for gastric cardia adenocarcinoma and risk for esophageal squamous-cell carcinoma were not increased.
      
 

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