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microvascular complications
Careful control of all risk factors, especially arterial hypertension in type 1 and type 2 diabetics is recommended, together with a strict glycemic control to reduce systemic microvascular complications.
      
In patients with diabetes mellitus, tight glycemic control has not been shown to reduce macrovascular complications such as stroke, but does reduce microvascular complications.
      
We speculate about the possibility that under dyslipidemias associated with increased exposure of vascular cells to NEFA, like in type 2 diabetes, similar alterations may contribute to associated macrovascular and microvascular complications.
      
Cutaneous manifestations of diabetes occur because of the microvascular complications of diabetes, impaired wound healing, and other yet undetermined mechanisms.
      
Hyperglycemia, insulin resistance, microvascular complications, and coexistent conditions have been shown to impair endothelial function in diabetes.
      
Yet, cardiovascular disease and other microvascular complications are very common, and both are dependent on control of blood pressure.
      
Microvascular complications and the diabetic pregnancy
      
Anemia has recently been recognized as a frequent complication of diabetic nephropathy, appearing earlier than in nondiabetic renal disease and amplifying the risks of cardiovascular and microvascular complications.
      
Hypertension is common in patients with diabetes and is a major risk factor for development and progression of the macro- and microvascular complications seen in diabetes.
      
Aggressive glycemic control alone will not reduce CHD events, but will prevent diabetes-specific microvascular complications.
      
The present investigation was dedicated to support biochemical interpretations of well-known long-term microvascular complications in diabetes.
      
Relation of diabetic control to development of microvascular complications
      
Diabetic patients have a high susceptibility to microvascular complications, atherosclerosis and thrombosis.
      
No relation between doublet formation rate and type of diabetes, treatment, or microvascular complications was observed.
      
Thus, tropical pancreatic diabetes in South India appears to be heterogenous with respect to level of nutrition, severity of glucose intolerance, B-cell function, response to therapy and the occurrence of microvascular complications.
      
Diabetic control and microvascular complications: The near-normoglycaemic experience
      
The relationships between changes in nerve function, glycaemic control and concurrently developing microvascular complications (retinopathy, microproteinuria) were investigated.
      
In addition, there was an association between developing neural and microvascular complications which was not diminished when their common relationship to hyperglycaemia was taken into account.
      
These findings suggest that, although poor glycaemic control is an essential permissive factor in the early development of diabetic polyneuropathy, other influences, shared with microvascular complications, must also be important.
      
We conclude that the in vivo effects of glycation on the clearance and transcapillary passage of albumin are small and not likely to play any significant role in the development of late diabetic microvascular complications.
      
 

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