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-cis retinoic acid
13-cis Retinoic Acid in Combination with Interferon-α Enhances Radiation Sensitivity of Human Squamous Cell Carcinoma Cells of t
      
Preclinical and clinical trials demonstrated the antiproliferative and chemopreventive potential of 13-cis retinoic acid in combination with interferon-α.
      
PPARα activated by fibric acids form heterodimers with the 9-cis retinoic acid receptor (RXR).
      
The impact of pretransplant cytoreductive treatment, such as intensive chemotherapy, splenectomy, or 13-cis retinoic acid, is unclear.
      
PPARs heterodimerize with 9-cis retinoic acid receptor (RXR), and bind to PP response element(s) (PPREs) on the target gene promoter to initiate inducible transcriptional activity.
      
A phase I-II study of 9-cis retinoic acid and interferon-α2b in patients with advanced renal-cell carcinoma: An NCIC Clinical Tr
      
The first two patients were in first and second relapse of their leukemia that had occurred despite maintenance treatment with 13-cis retinoic acid after chemotherapy-induced complete remission (CR).
      
An aromatic retinoid (Ro 10-9359) and 13-cis retinoic acid (Ro 4-3780) were fed by gastric tube to 170 male adult Syrian hamsters daily for 30 days.
      
Reduction of bacterial skin flora during oral treatment of severe acne with 13-Cis retinoic acid
      
Risk factors promote elevations of serum lipids in acne patients under oral 13-cis retinoic acid (isotretinoin)
      
Ten patients with conglobate acne were orally treated with 13-cis retinoic acid (1 mg/kg/day).
      
Influence of 13-cis retinoic acid on zymosan-induced chemiluminescence of granulocytes
      
The effect of 13-cis retinoic acid (Ro-4-3780) on zymosan-induced chemiluminescence (CL) of freshly drawn human blood and isolated granulocytes has been examined in vitro.
      
It was found that already 5 μg/ml of 13-cis retinoic acid in isolated granulocytes showed a significant enhancement in zymosan-induced CL.
      
The enhancement by 13-cis retinoic acid was completely inhibited by 10-5 M sodium azide, which is an inhibitor of myeloperoxidase activity.
      
These findings strongly suggest that 13-cis retinoic acid might stimulate myeloperoxidase-dependent CL.
      
The retinoids used were the TMMP analog of ethyl retinoate (Ro 10-9359), 13-cis retinoic acid, all trans retinoic acid and retinol (trans).
      
Quantitation of specific differentiation proteins showed that Ro 10-9359 and 13-cis retinoic acid partially inhibited the differentiation of the cultures.
      
Effect of topical application of 13-cis retinoic acid on skin of hairless rats and hairless mice
      
The potential effectiveness of topical 13-cis retinoic acid (13-cis RA) as a sebosuppressive agent was evaluated in hairless ("fuzzy") rats and hairless mice.
      
 

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