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compound library
Screening of an annotated compound library for drug activity in a resistant myeloma cell line
      
Virtual screening of a potential candidate compound library suggested that the most promising 15 bis-MEP derivatives on the list were mainly derived from (-)-MEP with conformations of (S,S) and (SR,RS) and with a 2- to 7-carbon linkage.
      
In this study, Hep27 was expressed as a His6 fusion protein, and subjected to a substrate screen, using a compound library of SDR substrates, comprising steroids, retinoids, sugars and carbonyl compounds.
      
To that end, new developments in large-scale cell biology and compound library design in silico have evolved to obtain data with higher predictability of clinical efficacy.
      
To that end, new developments in large-scale cell biology and compound library design in silico have evolved to obtain data with higher predictability of clinical efficacy.
      
The analysis of the MAY database directly offers the potential to expand the CBI compound library, but also provides a source for structural diversity in a format suitable for computer-assisted database searching and molecular design.
      
The resulting pattern of hits across the grid of theoretical receptor sites provides a measure of the molecular diversity of the compound library.
      
The compound collection was composed of confirmed potent factor Xa inhibitors and a subset of the LeadQuest? screening compound library.
      
The selected reaction sequence allows the production of a highly diverse small-molecule combinatorial compound library.
      
Using this novel methodology, the synthesis of a diverse 96-compound library has been achieved.
      
About a one million (982,889) commercially available compound library (CACL) has been tested using this process.
      
Screening of a compound library using an EGF-RTK enzyme prepared from human tumour derived A431 cells identified a series of potent (IC50>amp;lt;1μM) enzyme inhibitors.
      
Thus, this method allows for a rapid generation of enzyme specificity information and can be used towards synthesis of new carbohydrate compounds and expand the glycan array compound library.
      
Activity of a number of compounds in the 200-compound library assayed was found to be linked to FtsZ inhibition.
      
Biotron is currently working through its compound library14 looking for the drug that best hits p7 while retaining good drug-like properties.
      
Compound 18 was selected from a 50000-compound library including synthetic compounds and natural products.
      
Discovery and characterization of a novel nonsteroidal antagonist A compound library of approximately 100,000 chemicals was run in the GR-VP16 assay.
      
In this study we describe a search for such antivirals by screening a compound library using a saliva-based blocking assay.
      
This two-volume set covers virtually everything you would need to know about compound library design and synthesis --including the general basics.
      
The Chembridge DIVERSet 10,000 compound library was screened in ture-activity relationship of their inhibitory properties.
      
 

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