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Synthesis of lactosylated piperazinyl porphyrins and their hepatocyte-selective targeting
      
It is suggested that such novel lactosylated piperazinyl porphyrins, as potential hepatocyte-selective targeting drugs, thus show promising activity in photodynamic therapy.
      
And we used this two-hybrid library to screen FOXA3, a hepatocyte nuclear factor, and found out an interacting protein: complement component C3.
      
Relationship between expression of hepatocyte grow factor and apoptosis of trophoblasts in hypertensive disorder complicating pr
      
Hepatocyte ballooning was observed in 94.6% of all 130 cases.
      
We suggest that the role of portal inflammation should be emphasized besides hepatic steatosis, lobular inflammation, hepatocyte ballooning and fibrosis in diagnosis and evaluation of NAFLD.
      
We studied the effects of the chelating agents of extra- and intracellular calcium ions, EGTA and BAPTA-AM, and of the inhibitor of Ca2+release from the reticulum, TMB-8, in the kinetics of protein synthesis in hepatocyte cultures.
      
Previously we demonstrated synchronized oscillations of protein synthesis rate in hepatocyte cultures upon accumulation of monosialoganglioside GM1 in the medium or after introduction of exogenous GM1 to the medium.
      
The synchronized oscillations of the protein synthesis rate in dense hepatocyte cultures were blocked 30 min after their treatment with 10-20 μM BAPTA-AM, a chelating agent of cytoplasmic calcium.
      
Hepatocyte proliferation in the liver regenerating after partial hepatectomy ceases when the organ is restored, and the mechanism of this phenomenon is still unclear.
      
The medium conditioned by dense, self-synchronized hepatocyte cultures was centrifuged at 150?000 g to obtain two fractions.
      
Diluted hepatocyte cultures with asynchronous fluctuations of protein synthesis proved to be synchronized by both the initial conditioned medium and its vesicular fraction.
      
Thus, GM1 as a component of membranes and monolayer lipid structures proved to be much more effective than free GM1 in promoting hepatocyte cooperation with respect to the rhythm of protein synthesis.
      
In contrast to control, the hepatocyte cytoplasm: (1) contained a lot of glycogen; (2) there were many lipid droplets, which directly contacted glycogen granules; and (3) had more abundant peroxisomes.
      
The obtained data indicate that hepatocyte apoptosis after bile outflow restoration in late cholestasis can be due to the activation of the sphingomyelin cycle, LPO, and TNFα expression.
      
Silybin reduces lipid peroxidation of rat hepatocyte membrane caused by cyclosporin A
      
However, incubation of isolated macrophages in the presence of dextran sulfate and such medium transfer into hepatocyte culture results in even more pronounced increase in TAT activity.
      
The Mechanisms of Endogenous Control of Hepatocyte Proliferation Are Different in Mice of Two Inbred Strains (BALB/c and AKR)
      
The gene for the hepatocyte growth factor (HGF), a c-Met ligand, was transcribed in VMR-P but not in VMR-0 tumor.
      
Kinetic Modeling of Energy Metabolism and Superoxide Generation in Hepatocyte Mitochondria
      
 

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