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early pancreatic
Pdx-1, an important transcription factor highlighting in the early pancreatic development, islet functions and pancreatic disorders, needs to be more investigated in zebrafish, and siRNA is still seldom applied in zebrafish embryo-related research.
      
Only when we understand early pancreatic neoplasms will be able to detect tumors that are curable with surgical resection.
      
Recently detection of 18q deletions (at the DPC4 locus) in pancreatic secretions from early pancreatic cancers was also reported.
      
These advances raise the possibility that within well defined at risk groups it will be possible to use a combined set of molecular markers to screen clinical samples and detect early pancreatic cancer or even premalignant lesions.
      
The homeodomain protein PDX-1, an insulin gene transcription factor, is uniformly expressed in the early pancreatic bud, and null mutation of PDX-1 in mice results in a failure of the pancreatic bud to grow and differentiate.
      
We have developed a model of severe hyperstimulation and obstruction pancreatitis (SHOP) to better define the mechanisms of early pancreatic fibrogenesis.
      
In conclusion, SHOP is a novel model of early pancreatic fibrosis associated with minimal necrosis and a significant decrease in acinar cell mass, making it an ideal model to study the early cellular mechanisms of pancreatic fibrogenesis.
      
Early pancreatic ductal adenocarcinoma: Definition, diagnosis, and prognosis
      
Early pancreatic ductal adenocarcinomas may be defined as tumors limited to the duct epithelium without invasion to the parenchyma.
      
To determine the tumor size that constitutes early pancreatic cancer, we reviewed and analyzed the English-language and Japanese literature (a total of 25 publications) on small pancreatic cancers less than 2 cm in diameter and/or stage 1 cancers.
      
Usefulness of Simple Endoscopic Aspiration Cytology of Pancreatic Juice for Diagnosis of Early Pancreatic Neoplasm (A Prospectiv
      
Expression of seven of these Sox factors was studied in more detail by in situ hybridization from the stage of early pancreatic outgrowth to birth.
      
It is unclear whether abnormal stimulation of PP by defined meals is of value in diagnosing early pancreatic involvement in patients with MEN-1.
      
Molecular analyses of pancreatic cancer have also led to the development of a number of potential screening tests for early pancreatic cancer.
      
Pdx-1 and Nkx6.1 are markers of the early pancreatic epithelium.
      
Pdx-1 is a transcription factor that is expressed during early pancreatic development, during islet cell differentiation, and in the mature b-cell.
      
Treatment of early pancreatic explants with TATngn3 results in preferential differentiation into glucagon-producing cells.
      
Thus a blood test that is highly sensitive and specific for early pancreatic cancer would be a major advance in the diagnosis of this disease.
      
There is scope for studies on early pancreatic lesions by immunoperoxidase methods.
      
These data suggest that an interaction between S100P and S100PBPR may be involved in early pancreatic cancer.
      
 

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