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Synthesis and Cytotoxic Activity of 6-(Substituted-Phenyl)Amino-5,8-Quinazolinediones
      
Design, Synthesis and Growth Inhibition Activity of Bis-Epoxyethyl Derivatives of Stallimycin Modified on the Amidino Moiety
      
BIOLOGICAL ACTIVITY AND NEW TRENDS IN THE CHEMISTRY OF ISOQUINOLINE ALKALOIDS
      
Statistically significant correlation (r>amp;gt;0.905) was obtained between the physicochemical parameters and biological activity.
      
These studies may be useful in designing molecules with better cyclooxygenase-2 inhibitory activity.
      
The aqueous and solvent extracts when tested against 11 gram-negative and 2 gram-positive bacteria and 3 fungi expressed activity to most of the organisms.
      
Activity was not recorded for hexane extract, against A.
      
Methanol extract showed more activity amongst all the solvent extracts, particularly remarkable activity recorded against gram-positive bacteria.
      
Activity against diarrhea and dysentery causing organisms such as A.
      
PHYTOCHEMICAL CONSTITUENTS AND ANTIMICROBIAL ACTIVITY FROM THE STEMS OF JATROPHA MAHESHWARII
      
Aqueous and organic solvent extracts tested by agar-well diffusion method against 12 human pathogenic bacteria and 3 fungal strains showed activity to most of the organisms.
      
Beginnings have been made by firms and research organizations to confront the challenges ahead by increasing R>amp;amp;D investment, patenting activity and adopting novel strategies.
      
The following structure has been determined for the repeating unit: →6)-α-D-Glcp-(1→ This fraction exhibited significant macrophage activity through the release of nitric oxide
      
Several 1-(substituted phenoxy)-3-{[4-(4-trifluoromethyl) phenoxy] piperidin-1-yl} propan-2-ols (str.II) were prepared in a six-step reaction sequence starting from methylamine and ethyl acrylate and evaluated for antidepressant activity.
      
The compounds were fully characterized by spectral and elemental analyses, and were tested for their effect on gross behavior, antireserpine and anorexigenic activity.
      
No effect was observed on gross behavior and some of them showed fluoxetine like antireserpine and anorexigenic activity.
      
This suggests that the rapid initial reduction in percent parasitemia may be due to α- isomer and the activity is maintained by the β- isomer.
      
Various physicochemical descriptors ere correlated with the biological activity out of which descriptors belonging to the family of electronic, spatial, structural and conformational were found to be of importance to the activity.
      
In the CoMSIA model, steric, electrostatic, hydrophobic and hydrogen bond donating factors were correlated to the activity and later the favorable and unfavorable regions of interaction were obtained.
      
The models obtained may be used as useful tools for predicting whether a molecule of pharmacological interest bears structural features likely to possess CETP inhibitory activity prior to synthesis.
      
 

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