助手标题
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
共[2]页 共[32]条 当前为第1条到20条
 

相关语句
lupus mice
Prostaglandin E2-mediated dysregulation of proinflammatory cytokine production in pristane-induced lupus mice
      
Our results showed that levels of serum and BAL PGE2 and LPS-stimulated production of PGE2 by peritoneal macrophages were remarkably increased in pristane-induced lupus mice compared to healthy controls.
      
Exogenous PGE2 enhanced production of IL-6, IL-10, and NO but decreased TNF-α by macrophages and augmented IFN-γ, IL-6, and IL-10 by splenocytes from pristane-induced lupus mice compared to healthy controls.
      
Exogenous PGE2 also enhanced production of IFN-γ, IL-6, and IL-10 by thymocytes from pristane-induced lupus mice.
      
Indomethacin (Indo), a PGE2 synthesis inhibitor, greatly inhibited LPS-induced production of IL-6 and IL-10 by macrophages from pristane-induced lupus mice, while enhanced TNF-α.
      
Indo remarkably inhibited Con A-increased production of IFN-γ, IL-6, and IL-10 by splenocytes and thymocytes from pristane-induced lupus mice.
      
Therefore, our findings suggest that endogenous PGE2 may mediate dysregulation of production of proinflammatory cytokines, such as IL-6, IL-10, and IFN-γ, and NO in pristane-induced lupus mice.
      
Medication with danazol began 40 days after birth of the mice and resulted in a significant decrease in proteinuria in female but not male lupus mice.
      
The concentration of SAP, an acute phase reactant, was significantly decreased in danzoltreated female lupus mice at 80, 100, 120, 140 and 160 days of age when compared to vehicle-treated control mice.
      
SAP levels in male lupus mice treated with danazol were significantly lower than normal control levels only at the 120 and 160 day time points.
      
TLR-9 Activation of Marginal Zone B Cells in Lupus Mice Regulates Immunity Through Increased IL-10 Production
      
The abnormal IL-10 response in lupus mice was derived from B cells with the marginal zone phenotype, and could be downregulated with inhibitory ODNs.
      
Additional studies were performed to confirm the EDV transcript was increased in the kidneys of lupus mice.
      
Antibodies to dsDNA as well as to nucleosomes can be eluted from kidney specimens of lupus mice with overt glomerulonephritis w2x.
      
Bindarit prolongs survival and reduces renal damage in NZB/W lupus mice.
      
Furthermore, sera and kidney eluates from lupus mice with active nephritis displayed high titers of antiactinin Abs.
      
Furthermore, kidney Ig eluates and sera from lupus mice contained high titers of IgG anti-actinin Abs.
      
High titers of anti-actinin Abs were present in sera and kidney eluates of lupus mice with active nephritis.
      
Indeed, we noted that interstitial cells expressed FasL in lupus mice with combined glomerular and tubulointerstitial nephritis.
      
In addition to being dsDNA reactive, sera from lupus mice are well recognized to be highly nephrophilic.
      
 

首页上一页12下一页尾页 

 
CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社