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alzheimer ' s disease
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
      
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
      
Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
      
Prospects of Non-drug Approaches to Alzheimer's Disease
      
According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
      
β-Amyloid peptide (Aβ), a normal constituent of neuronal and non-neuronal cells, has been proved to be the major component of extracellular plaque of Alzheimer's disease (AD).
      
A significant proportion of early onset Alzheimer's disease (AD) is caused by mutations in human genes for amyloid precursor protein (APP), presenilins 1 and 2 (PSEN1,2).
      
Missense mutations in human presenilin 1 gene (hPS1) cause an autosomal dominant, early onset form of Alzheimer's disease (AD).
      
The results suggest that bulbectomy initiates in the brain a pathological process similar to human Alzheimer's disease in location, biochemistry, and behavioral manifestations.
      
Among three isoforms, the apoE4 isoform is associated with increased frequency of atherosclerosis and Alzheimer's disease (AD).
      
Impaired Processes of Working Memory in the Monkey Model of Alzheimer's Disease
      
Alterations of the Sensory and Cognitive Components of Operative Memory in a Monkey Model of Alzheimer's Disease
      
Studies of the molecular mechanisms of Alzheimer's disease (AD) have led to two major achievements.
      
The neuroprotective effect of Thr-Gly-Glu-Asn-His-Arg hexapeptide (HLDF-6), a biologically active fragment of the differentiation factor of human leukemia cells (HLDF), was demonstrated on models of Alzheimer's disease in vivo and in vitro.
      
An increase in the dihydrotestosterone (DHT) content was demonstrated in the blood plasma of rats with the syndrome of Alzheimer's disease and in the medium of the culture of hippocampal neurons in the presence of the Aβ(25-35) peptide.
      
New approaches to the immunotherapy of Alzheimer's disease with the synthetic fragments of α7 subunit of the acetylcholine recep
      
Thus, the development of immunotherapy with peptide (159-167)-(179-188) seems to be a promising approach to prophylaxis and treatment of Alzheimer's disease.
      
Genetic Association between the Apolipoprotein E (APOE) Gene and Different Forms of Alzheimer's Disease
      
Allele ε4of the apolipoprotein E (APOE) gene is associated with higher risk for family or sporadic Alzheimer's disease (AD) in many, though not all, ethnic groups.
      
Galantamine is widely used for the treatment of Alzheimer's disease.
      
 

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