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inducing differentiation
Tributyrin has been shown to be cytostatic to tumor cells by inducing differentiation and apoptosis.
      
TGF-Β (1 ng/ml) reduced cell growth without inducing differentiation and was not associated with any change in [Ca2+]i.
      
Inducing differentiation by increasing the calcium concentration of the medium from 70 ΜM to 1.5 mM resulted in a marked decrease in c-myc RNA levels to 26% of control levels within 8 h.
      
TGFΒ (2 ng/ml), which inhibits keratinocyte growth without inducing differentiation, did not alter c-myc RNA levels over a 4-day period.
      
Plant and animal tissues killed by boiling were considerably less effective in inducing differentiation in the tissue.
      
Among the compounds we tested, 1-octadecyl-2-pyrimidinyl-3-[3-(5-carboxylatepenty)imidazolioethoxyethyl]glycerol (compound I) was the most effective in inducing differentiation of HL-60 cells.
      
The kinetics of induction of Hox1.6 and c-jun mRNA during three different ways of inducing differentiation in teratocarcinoma F9
      
leaves cultured in vitro has been studied, noting nutritive, hormonal, and environmental factors inducing differentiation and development of adventitious shoots.
      
Our data suggest that the method of inducing differentiation in skeletal muscle cells modifies not only the course of development but also the interaction of depolarization-dependent and purinergic pathways.
      
Attempts at inducing differentiation in various explants of Albizzia lebbeck resulted in the production of abundant shoot buds from the hypocotyl, root, cotyledon and leaflet explants, both directly and indirectly (i.e.
      
It is interesting to note that the cAMP pathway remains responsive to an elevated cAMP level in inducing differentiation in NB cells in spite of chromosomal anomalies and genetic changes associated with the maintenance of a cancer phenotype.
      
'One-gene' products offer potential opportunities for new approaches to cancer treatment and the hope of inducing differentiation of cancer cells toward their normal counterparts.
      
Ultimately, these pathways may provide attractive targets for the development of therapy aimed at inducing differentiation or programmed cell death in these tumors.
      
This implies that degree of morphological differentiation may be determined by size of the soma when using this technique for inducing differentiation.
      
Among them, DMDC was the most potent in inducing differentiation and inhibiting the growth of NB4 cells.
      
Arsenic exerts a dual effect on APL cells, inducing differentiation at low concentrations but apoptosis at relatively high concentrations.
      
Adipofibroblasts were treated with the three different defined media to determine which was the most effective at inducing differentiation.
      
Bufalin has the activities of inducing differentiation and apoptosis of tumor cells.
      
Compounds that are active in inducing differentiation share several characteristics.
      
Cell lysates were prepared on the indicated days after inducing differentiation.
      
 

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