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bupivacaine
Effects of levobupivacaine and bupivacaine on rat myometrium
      
Objective: To study the effect of levobupivacaine and bupivacaine on the contractility of isolated uterine muscle strips from pregnant and non-pregnant female rats.
      
In the myometrium from non-pregnant rats,-logIC50 of levobupivacaine and bupivacaine were 4.85 and 4.25 respectively.
      
In the myometrium from pregnant rats, similar concentrations of levobupivacaine and bupivacaine were observed,-logIC50 were 2.7 and 2.9 respectively.
      
Levobupivacaine produced an increase in amplitude of contractions, while bupivacaine showed an increased trend in frequency.
      
Conclusion: These results demonstrate that levobupivacaine and bupivacaine may inhibit myometrium contractility.
      
The inhibitory effect of levobupivacaine or bupivacaine is not enhanced by gestation in rat.
      
Levobupivacaine may have more positive influence than bupivacaine in pregnant myometrium.
      
A chiral capillary electrophoresis system for the highresolution separation of the enantiomers of the local anaesthetics mepivacaine, ropivacaine, bupivacaine and prilocaine is described.
      
An HPLC procedure for the determination of six local anesthetics, bupivacaine, lidocaine, mepivacaine, procaine, propanocaine and tetracaine, in pharmaceutical silane ODS-2 C18 analytical column and spectrophotometric detection at 230 nm were used.
      
Efficient pre-concentration of ropivacaine and bupivacaine from plasma samples, both off-line prior to GC and in-line with LC-MS-MS, was demonstrated.
      
The sensitivities by SSI for tetracaine, benzoxinate, dibucaine, bupivacaine and mepivacaine were 4-16 times higher than those by APCI; those by SSI for procaine and lidocaine were equivalent to those by APCI.
      
A sensitive high performance liquid chromatographic (HPLC) method has been developed and validated for the simultaneous determination of four local anaesthetics: lidocaine, proparacaine, bupivacaine and oxybuprocaine.
      
The retention times for lidocaine, proparacaine, bupivacaine and oxybuprocaine were 5.74, 9.28, 16.84 and 26.26?min, respectively.
      
HPLC-UV-Vis method was linear in the range of 50-5,000?ng?mL-1 for lidocaine and proparacaine and 100-5,000?ng?mL-1 for bupivacaine and oxybuprocaine.
      
The limit of detection (LOD) was 25?ng?mL-1 for lidocaine, proparacaine and 30?ng?mL-1 for bupivacaine and oxybuprocaine.
      
The limit of quantification (LOQ) was found to be 50?ng?mL-1 for lidocaine, proparacaine and 100?ng?mL-1 for bupivacaine, oxybuprocaine.
      
A zero-order release rate was obtained for codeine, hydromorphone, and bupivacaine from PLGA (85 :15) rods.
      
We designed a controlled release system of pain relievers, mainly for opioids (morphine, M, codeine, C, and hydromorphone, HM), and a local anesthetic (bupivacaine, BP) in the form of poly(L-lactide-coglycolide) (PLGA) rods.
      
The effects of intraperitoneal tramadol, tenoxicam and bupivacaine on pain relief after laparoscopic gynecological procedures
      
 

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