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drug metabolites
Analysis of drug metabolites by gas chromatography-mass spectrometry using glass capillary columns
      
A comparative study of the chromatography of hydroxylated dialkyldithiocarbamates as models for drug metabolites
      
Hydroxylated dialkyldithiocarbamates have been used as model compounds to test the suitability of packed column supercitical fluid chromatography for the analysis of drug metabolites.
      
The strong retention of the ionised glucuronide and sulphate conjugates of morphine is a particularly useful feature of the porous graphitic carbon packing material which has general applicability to the analysis of polar or ionised drug metabolites.
      
Covalent binding of drug metabolites to DNA - a tool of predictive value
      
The presently available data suggest at least some correlation between covalent binding of drug metabolites to DNA and carcinogenicity of that drug.
      
Sex differences in the cellular defence system against free radicals from oxygen or drug metabolites in rat
      
The total capacity of the cellular systems that detoxify reactive oxygen species or free radical-drug metabolites seems to be higher in female liver as compared to male.
      
We conclude that more comprehensive studies of drug metabolites are required for an improved understanding of their clinical effects.
      
This assumption is being increasingly questioned in recognition of the role of active drug metabolites.
      
Anti-apomorphine effects of phenothiazine drug metabolites
      
The pattern of monoamine uptake inhibition following sibutramine HCl administration to man is similar to that observed in sibutramine HCl-treated rats, and probably at least partly reflects inhibition of uptake by drug metabolites in both species.
      
Recent advances in analytical techniques have enabled the detection of drugs and drug metabolites in oral fluid specimens.
      
The correlation between typical functional groups found in phase I and phase II drug metabolites and corresponding neutral losses is generalized and illustrated for selected examples.
      
The present study shows that not only the excretion of unchanged drugs may decline with increasing age but also that of drug metabolites, which may therefore reach higher plasma levels in old patients.
      
Urinary drug metabolites were analysed by high pressure liquid chromatography.
      
Biotransformation of racemic warfarin by the fungus Beauveria bassiana IMI 12939 was studied as part of an investigation into alternative methods for the production of drug metabolites.
      
Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in E
      
Three human cytochrome P450s, 3A4, 2C9 and 1A2, were each co-expressed with NADPH-P450 reductase in Escherichia coli and used in the preparative synthesis of drug metabolites.
      
The results indicate that the harmfulness of the drug metabolites should be taken into consideration in the ecotoxicological studies.
      
 

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