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β-thalassemia major
This study explores the psychosocial problems experienced by families with children aged 6 to 14 years suffering from β-thalassemia major (N=188).
      
In order to identify the distribution of gene types of β-thalassemia and reduce the birthrates of β-thalassemia major in Guiyang area, 1054 pregnant women and their spouses from Affiliated Hospital, Guiyang Medical College were screened.
      
Among the 4 cases subject to prenatal gene diagnosis, one fetus was completely normal and 3 fetuses were diagnosed as having β-thalassemia major (1 homozygous and 2 compound heterozygous).
      
The fetuses diagnosed as β-thalassemia major were selectively terminated within two weeks.
      
It was concluded that the birthrate of β-thalassemia major in Guiyang area was reduced and the target of improving birth outcome and child development has been achieved.
      
Pituitary gland height evaluated by MR in patients with β-thalassemia major: a marker of pituitary gland function
      
In transfusion-dependent β-thalassemia major, increased iron deposition in the pituitary gland has a cytotoxic effect leading mainly to hypogonadotropic hypogonadism.
      
In 29 patients with β-thalassemia major and 35 age- and gender-matched controls the pituitary gland height was evaluated in a midline sagittal scan using a spin echo T1-weighted (500/20 TR/TE) sequence.
      
Immune status of Greek patients with β-thalassemia major negative for anti-HIV
      
The activity of reticuloendothelial system (RES) was estimated in 19 patients with β-thalassemia major, 20±4 years old, who had undergone successful splenectomy 6±5 years previously.
      
Recombinant human erythropoietin therapy in a transfusion-dependent β-thalassemia major patient
      
We report on a 28-year-old patient with transfusion-dependent β-thalassemia major, who was treated effectively with recombinant human erythropoietin (rHuEpo).
      
rHuEpo treatment seemed to have had a beneficial effect and to have improved the quality of life in β-thalassemia major, although it did have a slight effect on HbF levels, suggesting other possible mechanisms of rHuEpo action.
      
Growth hormone (GH) deficiency in patients with β-thalassemia major and the efficacy of recombinant GH treatment
      
Patients with β-thalassemia major still suffer growth retardation.
      
In patients with β-thalassemia major, growth retardation is a common complication and GH deficiency plays an important role.
      
Thirty-seven patients had β-thalassemia major, 9 patients had β-thalassemia intermedia, and 12 patients had sickle/β+-thalassemia.
      
Tricuspid regurgitation in patients with β-thalassemia major
      
Echocardiography was performed in 39 patients with β-thalassemia major and 35 aged-matched controls.
      
Occurrence of TR in patients with β-thalassemia major may be a consequence of cardiac iron deposit, thrombocytosis, splenectomy, or pulmonary hypertension.
      
 

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