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cyclic gmp
This suggests that cyclic GMP plays a role in the control of myocardial metabolism, and that the sensitivity of myocardial O2 consumption to changes in cyclic GMP is reduced by renal hypertension-induced cardiac hypertrophy.
      
Cyclic GMP was higher in the LVH animals during all treatments and was elevated from baseline by Ach in both groups.
      
Neither Iso nor Iso+Ach had a significant effect on cyclic GMP.
      
This does not, however, appear to be dependent on a cyclic GMP-mediated mechanism.
      
Cyclic GMP attenuates cyclic AMP-stimulate inotropy and oxygen consumption in control and hypertrophic hearts
      
Cyclic GMP (pmol/g) was unchanged by ISO in CON and HYP, and increased by SIN-1 in CON (8.1 ± 1.3 to 19.2 ± 2.3 EPI) and HYP (9.1 ± 1.5 to 12.8 ± 2.0 EPI).
      
Cyclic GMP remained elevated with ISO+SIN-1 in both groups.
      
The current study demonstrated attenuation of cyclic AMP mediated increased inotropy and O2 consumption by increasing cyclic GMP, which appeared, in part, related to cyclic GMP-induced reduction in cyclic AMP.
      
This effect of cyclic GMP on cyclic AMP was not observed in myocardial hypertrophy.
      
Interaction between the opposing functional effects of cyclic AMP and cyclic GMP in hypertrophic cardiac myocytes
      
We conclude that in control and hypertrophic myocytes, the effects of cyclic GMP were blunted after forskolin, but this did not seem to be related to cyclic AMP phosphodiesterase activity.
      
To investigate these mechanisms, we observed the effects of 8-bromo-cyclic GMP (8br-cGMP) on myofibrillar Ca2+ sensitivity and Ca2+ handling of the sarcoplasmic reticulum (SR) using β-escin-skinned preparations from Wistar rat hearts.
      
Somatostatin, substance P, cyclic AMP and cyclic GMP were determined in the cerebrospinal fluid of patients with Huntington's disease, in first generation relatives of choreic patients and in neurological control patients.
      
Cyclic AMP was decreased only in patients with advanced stages of the disease while cyclic GMP was normal.
      
The biological activity of irANP produced by such engineered VSMCs was evidenced by cyclic GMP (cGMP) activation in LrASN-transduced VSMCs or in VSMCs exposed to conditioned media harvested from VSMCs secreting irANP.
      
The AT2 receptor mediates a renal vasodilator cascade, including generation of bradykinin, nitric oxide, and cyclic GMP.
      
The AT1 and AT2 receptors engage in inter-receptor "cross-talk." In the absence of the AT2 receptor, sustained angiotensin II pressor and antinatriuretic hypersensitivity occurs, mediated by a deficiency of bradykinin, nitric oxide, and cyclic GMP.
      
The AT2 receptor stimulates a bradykinin (BK)-nitric oxide (NO)-cyclic GMP vasodilator cascade in blood vessels and in the kidney.
      
Effect of icariin on cyclic GMP levels and on the mRNA expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in peni
      
cDNAs encoding two PDE-3 or cyclic GMP-inhibited (cGI) cyclic nucleotide phosphodiesterase (PDE) isoforms, RPDE-3B (RcGIP1) and HPDE-3A (HcGIP2), were cloned from rat (R) adipose tissue and human (H) heart cDNA libraries.
      
 

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