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cyclic gmp
All active recombinants exhibited a high affinity (>amp;lt;1 μM) for cyclic AMP (cAMP) and cyclic GMP (cGMP), were inhibited by cAMP, cGMP, and cilostamide, but not by rolipram, and were photolabeled with [32P]-cGMP.
      
Cyclic GMP modulates the expression of Gi protein and adenylyl cyclase signaling in vascular smooth muscle cells
      
Estradiol and progesterone modulate the nitric oxide/cyclic GMP pathway in the hypothalamus of female rats and in GT1-1 cells
      
Cyclic GMP is probably involved in this hormonal regulation.
      
Ghrelin reduces voltage-gated potassium currents in GH3 cells via cyclic GMP pathways
      
Four peptides decrease human colon adenocarcinoma cell number and DNA synthesis via cyclic GMP
      
Cyclic GMP alterations in fetal rat cerebrum after global intrauterine ischemia: Role of guanylate cyclase phosphorylation
      
Changes in the levels of cyclic AMP (cAMP) and cyclic GMP (cGMP) have been measured in brains of 20-day-old rat fetuses exposed to global intrauterine ischemia.
      
In most known cases, invertebrate phototransduction involves polyphosphoinositide and cyclic GMP (cGMP) intracellular biochemical signaling pathways leading to opening of plasma membrane ion channels.
      
Role of the nitric oxide/cyclic GMP/Ca2+ signaling pathway in the pyrogenic effect of interleukin-1β
      
Potential downstream effectors of NO include the second messenger cyclic GMP, activation of the tumor-suppressor genes p53 and Rb, and the cyclin-dependent kinase inhibitor p21.
      
This review focuses on cyclic GMP signaling and describes recent advances in understanding the properties and functions of guanylyl cyclases in invertebrates.
      
Hormones and neurotransmitters which increase cytoplasmic cyclic AMP, cyclic GMP, calcium or phospholipid-derived second messengers are potent secretagogues.
      
ANF raises cyclic GMP in target cells and activates particulate guanylate cyclase but not soluble guanylate cyclase.
      
Concomitant increase in plasma atrial natriuretic peptide and cyclic GMP during volume loading
      
Decreased plasma levels of cyclic GMP in patients with chest pain and angiographically normal coronary arteries
      
The concentration of cyclic GMP in plasma was significantly lower (by at least three-fold) in patients with suspected spasm angina, as compared with the other groups.
      
We tested the resulting hemodynamic and renal effects as well as the effect on plasma cyclic GMP levels and compared them with the properties of platelet ANF receptors.
      
The ANF injection evoked an increase in cyclic GMP plasma levels of 19.3±2.2 nM in healthy controls.
      
Correlation analysis showed that the relationship between the actions of ANF and the increases in plasma cyclic GMP levels is loose and cannot predict the hemodynamic or renal effects of exogenous ANF in a given patient.
      
 

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