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cyclic gmp
Although the behavior of plasma cyclic GMP levels fails to predict the responsiveness of the body to ANF in a given patient, it does reflect the differences between the patient groups and the control group.
      
We also measured plasma levels of guanosine 3'∶5'-cyclic monophosphate (cyclic GMP) as SIN 1, the bioactive metabolite of molsidomine, becomes effective via activation of soluble guanylate cyclase.
      
Despite the effect on platelets, plasma cyclic GMP levels did not increase.
      
The soluble form of guanylate cyclase in vascular smooth muscle, an enzyme which produces the intracellular mediator of relaxation cyclic GMP, is also a site of action of vasoactive O2 metabolites.
      
These cyclic GMP-mediated mechanisms of relaxation are inhibited by superoxide anion, produced from endogenous sources after inhibition of superoxide dismutase or produced by pharmacological agents that undergo redox cycling.
      
Releasing hormone administration did not affect ANF and cyclic GMP plasma levels.
      
Altered modulation of cyclic GMP (cGMP) levels in the brain seems to be responsible for the impairment of some types of cognitive function in liver disease.
      
Cyclic GMP in blood and minimal hepatic encephalopathy: fine-tuning of the diagnosis
      
Induction of tyrosine aminotransferase by insulin not mediated by cyclic GMP
      
Interleukin-1β effects on cyclic GMP and cyclic AMP in cultured rat islets of Langerhans - arginine - dependence and relationshi
      
When islets were cultured with interleukin-1β (1 or 100 pmol/l) for 12 h in arginine-containing medium, cyclic GMP levels were increased 1.6- and 4.5-fold respectively.
      
The arginine analogue, N-ω-nitro-l-arginine methyl ester, which blocks nitric oxide formation and partially reverses inhibition of insulin secretion by 100 pmol/l interleukin-1β, largely, but not completely, blocked generation of cyclic GMP.
      
The morpholinosydnonimine SIN-1, which is a nitric oxide donor, inhibited insulin secretion, raised islet cyclic GMP and lowered cyclic AMP; its effects were similar to those of interleukin-1β.
      
However, 6-anilinoquinoline-5,8-quinone, [LY83583 (1-10 μmol/l)], inhibited insulin secretion, and significantly decreased cyclic GMP while 8-bromocyclic GMP stimulated insulin secretion.
      
Both low- and high-dose interleukin-1β treatment give a large arginine-dependent and a small, yet significant, arginine-independent increase in cyclic GMP.
      
Three to four weeks after streptozotocin injection, the plasma concentration of ANP, urinary cyclic GMP excretion rate, GFR, and RPF were significantly higher in diabetic rats than in control rats.
      
A specific protein kinase A inhibitor, H-89, suppressed increases in nitrite/nitrate and cyclic GMP (cGMP) and protein kinase A activity stimulated by DBC or BPS.
      
Furthermore, the impaired cyclic GMP in RFL-6 detector cells (an index of NO activity) generated by bradykinin-stimulation of high glucose-exposed endothelial cells was restored to normal by pretreatment with PDTC.
      
Cyclic GMP rose from 0.74 ± 0.01 to 2.62 ± 0.10 pmol/106 cells at 30 min (p = 0.0001); cAMP rose from 0.9 ± 0.09 to 11.65 ± 0.74 pmol/106 cells at 15 min (p = 0.0001).
      
Cyclic nucleotide phosphodiesterases (PDEs) comprise a family of enzymes (PDE1-PDE11) which hydrolyse cyclic AMP and cyclic GMP to their biologically inactive 5' derivatives.
      
 

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