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cyclic gmp
A role for heterotrimeric GTP-binding proteins and ERK1/2 in insulin-mediated, nitric-oxide-dependent, cyclic GMP production in
      
Plasma cyclic GMP levels decreased without a significant change of atrial natriuretic factor levels.
      
Cyclic AMP and cyclic GMP in germinating conidia of Neurospora crassa
      
The enzyme was able to hydrolyse both 3',5'-cyclic AMP and 3',5'-cyclic GMP but did not hydrolyse 2',3'-cyclic AMP.
      
Pretreatment with diazepam completely abolished the effects of picrotoxin and harmaline and significantly reduced the effects of pentetrazol and oxotremorine on cyclic GMP levels, but the tremor due to harmaline and oxotremorine was not blocked.
      
Pretreatment with pentobarbital also prevented or strongly reduced changes in cyclic GMP levels elicited by excitatory drugs without abolishing the tremorigenic effects of harmaline and oxotremorine.
      
Pretreatment with atropine was only effective in blocking cyclic GMP rise and tremor induced by oxotremorine and picrotoxin.
      
Dopaminergic stimulants (amantadine, amphetamine, apomorphine, nomifensine and L-dopa plus benserazide) increased cyclic GMP levels in the medial forebrain and cerebellum of mice.
      
Drug-induced stereotyped behaviour correlated in intensity and duration to the changes in cyclic GMP levels in the medial forebrain.
      
The effects of dopaminergic stimulants on the cyclic GMP content in the medial forebrain and the cerebellum were studied in mice pretreated with dopaminergic antagonists, cholinolytics and agents enhancing GABAergic transmission.
      
Low doses of butyrophenones (haloperidol and spiroperidol) inhibited the rise in cyclic GMP levels and the stereotyped behaviour induced by amphetamine, but were without effect on the same biochemical and behavioural changes elicited by apomorphine.
      
Higher doses effectively blocked the rise in cyclic GMP levels and the stereotyped behaviour elicited by both drugs.
      
On the mechanism of the decrease in cerebellar cyclic GMP content elicited by opiate receptor agonists
      
Low doses of clonidine (0.1 mg/kg) caused sedation in mice and decreased cyclic GMP content in the cerebellum, but not in the medial forebrain.
      
High doses of clonidine (10.0 mg/kg) caused only a moderate and transient fall in cerebellar cyclic GMP content, the values returning to controls or above after 30 min, when behavioural excitation occurred.
      
The crossreactivity with cyclic GMP, ATP, ADP, 5'-AMP and adenosine is extremely low.
      
Cyclic AMP and cyclic GMP in the rat gastric mucosa
      
Effects of manganese on cyclic GMP levels in the rat ductus deferens
      
Cyclic GMP levels were increased 2 to 3-fold in guinea pig cerebral cortical slices by norepinephrine, histamine, and adenosine.
      
Cyclic GMP was applied to the rabbit right auricle by a cut-end method.
      
 

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