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signal induction
In Her2/neu overexpressing cancer cells, Fab63 is rapidly internalized and has significant antiproliferative effects, where ligand-independent mechanisms dominate signal induction.
      
However, question of a threshold and the nature of the damage that can signal induction of this pathway remain poorly understood.
      
IBN is neither phosphorylated nor proteolyzed in response to signal induction, but fully inhibits NF-B activation.
      
In these instances the release of extracellular constraints or clustering imposed by bound macromolecular hyaluronan is the likely signal induction23.
      
In all cases antibody potency was increased with respect to targeting and apoptotic signal induction.
      
The unexpected finding was how crucial signal induction was to separating patients according to therapeutic outcome.
      
 

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