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gi protein
These data provide evidence that the plasma membrane of starfish oocytes contains a 40-kDa GTP-binding protein with properties characteristic of the alpha subunit of the inhibitory Gi protein.
      
In cardiac fibroblasts AngII activated MAP kinases through a pathway including the Gβγ subunit of Gi protein, Src, Shc, Grb2, and Ras, while Gq and PKC activation was necessary in cardiac myocytes.
      
With the list of candidate genes for this disorder steadily increasing, the pertussis toxin-sensitive inhibitory G protein (Gi) protein β3 subunit (GNB3) gene has remained "sizzling," challenging the domination of the renin-angiotensin system.
      
Cyclic GMP modulates the expression of Gi protein and adenylyl cyclase signaling in vascular smooth muscle cells
      
They also confirm that the inhibitory action of dopamine is mediated through a Gi protein; and the stimulatory action of dopamine is mediated through a PTX-insensitive pathway.
      
Cell-cycle induction by C5b-9 is dependent on the activation of phosphatidylinositol 3-kinase and the ERK1 pathway in a Gi protein-dependent manner.
      
Histamine release from mast cells of EAE rats by Gi protein-dependent and IgE-dependent pathways
      
We investigated both Gi protein-dependent and IgE-dependent pathways that control release of histamine by PMCs derived from EAE or Complete Freund's Adjuvant (CFA) immunized rats.
      
All linkages were sensitive to pertussistoxinpre-treatment (IC50≈0.5-0.6 ng/ml × 4.5 h for all pathways), suggesting the involvement of Gi protein(s) in these signal transduction pathways.
      
β3-Adrenoceptor-selective agonists shorten the action potential and cause cardiodepression, suggesting direct coupling of a Gi protein to a K+ channel.
      
Whereas the amount of Gi protein appeared similar in all four clones, the amount of Gs protein was higher in clones 21 and 27 than in the other two clones.
      
In previous paper based on classical pharmacological tools, we identified a Gi protein-coupled presynaptic 5-hydroxytryptamine (5-HT) 1B receptor causing inhibition of dopamine (DA) release in rat striatal synaptosomes.
      
However, in feline and rodent myocardium, catecholamines and zinterol usually do not hasten relaxation through activation of β2-adrenoceptors, presumably because of coupling of the receptors to Gi protein.
      
Platelet α2-adrenergic receptor coupling efficiency to Gi protein in subjects with post-traumatic stress disorder and normal con
      
α2AR density in the high- and low-conformational states, agonist affinity in both states and coupling to Gi protein were investigated in 23 drug-free combat PTSD patients and 25 normal controls.
      
Results rule out dysregulation in α2AR coupling to Gi protein.
      
It is suggested that activation of the ANF receptor in human atrial cells reduces ICa via guanylate-cyclase-dependent cGMP production, increases ICa via Gs protein activation and decreases Ilo via Gi protein activation.
      
When the antibody against Gi protein was present in the pipette solution the stimulatory effect of isoproterenol disap-peared.
      
Pertussis toxin (PT) (10 μg/ml) was used to study the activity of the inhibiting G protein since it stimulates AC activity by inhibiting the inhibitory regulatory protein by adenosine diphosphate ribosylating the alpha subunit of the Gi protein.
      
This suggests that there is less Gi protein in the neoplasms since the AC response to PT was greater in normal tissues by 170%, but there was no significant stimulation in neoplastic tissues.
      
 

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