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cancer
Guanidine-like compounds have been investigated since the first observations of their therapeutic potential some 30 years ago in fields of cancer and virology.
      
Epidermal Growth Factor Receptor (EGFR) is among the growth factor receptor kinases that have been implicated in as being important in cancer.
      
Inhibitive Effect of Prodigiosin on the Proliferation of Human Malignant Pancreatic Cancer Cells
      
Pancreatic cancer is not only common, but also extremely difficult to treat, for which it has been called "the challenge of the twenty-first century".
      
In this study, we find that prodigiosin could effectively inhibit the proliferation of human pancreatic cancer cells H8898 in a dose-and-time-dependent manner, with an IC50 of 75μmol according to the results of MTT and cell proliferation assays.
      
Prodigiosin also could induce apoptosis of pancreatic cancer cells at low concentration and results in the fragmentation pattern of DNA.
      
All these results demonstrate that prodigiosin can obviously inhibit the proliferation of pancreatic cancer cells H8898 by arresting the cell cycle and inducing apoptosis.
      
A new series of 1,2,3-trisubstituted 2-(2-oxoalkyl)-2,3-dihydrobezimidazoles have been synthesized and evaluated for their cytotoxic activity using one normal (FL) and two cancer (RD and A2058) cell lines.
      
Compounds 4-21 were evaluated for cytotoxic activity against a panel NCI-H460 (lung), MCF7 (breast) and SF-268 (CNS) cancer cell lines.
      
The 'active' compounds, which reduced growth of cancer cells to ca.
      
32% or less, have been evaluated in a full panel of 60 human cancer cell lines over a 5-log dose range at the National Cancer Institute.
      
Several compounds have demonstrated growth inhibitory effects (GI50) in a wide range of cancer cell lines.
      
Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell pr
      
The title compounds were evaluated for their efficacy in inhibiting MDA-MB-231 breast cancer cell proliferation.
      
According to the protocol of the National Cancer Institute (NCI) in vitro disease-oriented human cells screening panel assay, 13 compounds showed promising broad spectrum antitumor activity.
      
All agents are cytotoxic nitrogen mustard agents, a class of drugs widely used in the clinical treatment of cancer.
      
The biological activity on cancer cells and the pharmacokinetics have also been evaluated, showing a very high liver-to-skin ratio and short retention time in tissues.
      
The model consists of a system of partial differential equations governing intra-tumoral drug concentration and cancer cell density.
      
Additionally, (2) also inhibited the proliferation of human erythroleukemia cancer cell line K562 with IC50 value of 49.1 μg/mL.
      
1 exhibited significant inhibitory activity against the human DNA topoisomerase I (hTopo I), the cancer cell lines BEL-7402 and MCG-803, with the IC50 values 12.0, 6.5, and 8.0 μg/mL, respectively.
      
 

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