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contracture
Both in vivo and in vitro stimulation of σ receptors prevents the development of reperfusion contracture and creatine kinase release and increases the developed pressure, double product, +dP/dt, and -dP/dt in the left ventricle.
      
These patients should be transferred to a MH specialist to confirm susceptibility to MH by the in vitro contracture test with caffeine and halothane with a sensitivity of >amp;gt;99% and a specificity of 94%.
      
However, a genetic test can replace the invasive in vitro contracture test only in families with a known RYR1 mutation.
      
A change to normal perfusion fluid causes a period of contracture to occur.
      
Barium, ouabain and hypoxia cause contracture and reduce the size of the extracellular space.
      
X-ray microanalysis was used to compare chemically untreated cryosections of quick-frozen myocardial tissue in "caffeine contracture" with cryosections of normal muscle.
      
Contracture type and fibrosis type of decreased myocardial distensibility.
      
Resting length-tension relationships were measured in rat trabecular muscle strips under control (O2) and contracture (N2) conditions as well as in preparations of Goldblatt II (8-week stage) and control rats.
      
Without Ca++ 0.5 mM Sr++ causes an immediate arrest, 2 mM Sr++ a complete contracture (14 min) and 5 mM a contracture after about 44 min.
      
Using stepwise 0.1 mm releases, length-tension relationships were recorded under control and contracture conditions in both types of contracture.
      
The slope of the Δδ/Δε-f(δ) function was not significantly changed in the low contracture compared to control conditions (n=8, n.s.) but showed a significant 42% increase in the severe contracture (n=8; p>amp;lt;0.001).
      
Additional morphological studies revealed uniform sarcomere lengths in low contracture, and two populations of sarcomere lengths in the severe contracture.
      
- On the basis of the present and earlier results, a model of contracture tension generation is proposed in which cross-bridges between actin and myosin cycle at a very low rate and are attached in a force-generating position for a long time.
      
The relationship between ischemic contracture and no-reflow phenomenon in isolated rat heart
      
The relationship between ischemic contracture and no-reflow phenomenon was studied in 59 isolated rat hearts during global ischemia.
      
The contracture was measured by a water-filled balloon catheter placed in the left ventricular lumen.
      
The time of the onset of contracture was changed by preischemic infusion with buffer containing 0.5 mmoles/l iodoacetate (IAA) in order to get early contracture, and by hypothermia which delayed the development of contracture.
      
The first signs of contracture were noticed in normothermia (37°C) at 11 minutes, in hypothermia (26°C) at 25 minutes, and in the IAA-infused group at 3 minutes.
      
The completion of contracture occurred in these groups at 25, 90 and 11 minutes, respectively.
      
It was concluded that the no-reflow phenomenon in isolated rat heart is closely associated with the development of myocardial contracture during global ischemia.
      
 

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