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HEPATOPROTECTIVE EFFECTS OF PICROLIV IN ALCOHOL-FED ALBINO RATS
      
A slightly elevated fasting blood glucose profile, 1.5 fold higher serum insulin levels and impaired glucose tolerance was prevalent in ethanol treated rats.
      
In the present study, the effect of picroliv, an irridoid glycosidic fraction of Picrorhiza kurroa, on the above said parameters of these alcoholic rats was studied.
      
Picroliv significantly reverted most of the above said altered blood and hepatic parameters in the alcohol-fed male and female rats to almost normal levels.
      
The pharmacokinetics of α- and β-diastereomers of Arteether, a well-known antimalarial drug and its active metabolite dihydroartemisinin (DHA) were studied in Sprague-Dawley rats, Rhesus monkeys and human volunteers.
      
Studies in rats revealed dose dependency/ non-linearity in arteether pharmacokinetics with in the dose levels used.
      
Overall the pharmacokinetic properties of both isomers were similar in rats, monkeys and humans, with β-isomer exhibiting longer elimination half-life, MRT, volume of distribution and clearance, irrespective of the route of administration.
      
But there appeared to be species difference in arteether metabolism, highest conversion being recorded with humans followed by rats and monkeys.
      
Diclofenac (25 mg kg-1) and meloxicam (7.5 mg kg-1) produced 9.3 and 19.6 mm2 ulcer areas in stomachs of rats, respectively, when used alone, but when combined with nimesulide diclofenac and meloxicam did not cause any injury in rat stomachs.
      
Mentha crispa extract or 0.9% NaCl were (15 days) administered daily by gavage to Wistar rats.
      
Combined treatment with niacin and chromium caused a protective effect on the small-intestine tissue of hyperlipidemic rats
      
The present study investigated whether a combined treatment of niacin and chromium (III) chloride caused a protective effect on the intestine of hyperlipidemic rats.
      
Hyperlipidemic rats displayed a reduction of the intestinal glutathione level and an increase in intestinal lipid peroxidation levels, and in serum cholesterol, total lipid and phospholipids levels.
      
Light microscopy revealed compressed villi, oedema, mononuclear cell filtration, and vacuolization on the cytoplasm of epithelial cells in the jejunum of hyperlipidemic rats.
      
Despite individual differences, degenerative findings were decreased in hyperlipidemic rats given niacin and chromium.
      
Niacin and chromium treatments had a protective effect on the intestine of the hyperlipidemic rats as well as a lipid-reducing effect.
      
A sensitive high-performance liquid chromatography (HPLC) method was established for the determination of concentration of 5-FU-1-acetic acid in the gastrointestinal contents and plasma of rats.
      
5-FU-PT was given to rats by oral administration at a dosage of 22.5?mg kg-1.
      
Evaluation of the efficacy of 99mTc-labeled ascorbic acid on common cold-cough drugs in rats
      
The aim of this study was to investigate the effect of cough-cold drugs on the uptake of ascorbic acid using 99mTc-ascorbic acid (99mTc-AA) in male albino Wistar rats.
      
 

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