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dna
A gene regulatory mechanism has been proposed in which steroid hormones and certain other drugs bind to nuclear receptor proteins followed by transfer to DNA where they are inserted between base pairs.
      
Here, we report using the estrogen receptor that the location of drugs in x-ray crystal structures of the receptors matches closely their predicted spatial locations in the DNA.
      
These findings provide compelling evidence that DNA is the ultimate target of these drugs that act on the human genome.
      
In the present study, two of the probable an umor marine compounds, manzamine A and sarcophine, were screened using benzo[a]pyrene (BP)-derived DNA adduct formation in MCF-7 cells as intermediary biomarker.
      
After 24h incubation, cellular DNA was isolated and analyzed for BP-derived DNA adducts by 32P-postlabeling technique.
      
Manzamine A and sarcophine increased the BP-DNA adducts by 2 to 4-folds.
      
The residual DNA repair ability was almost completely abolished by manzamine A while sarcophine was ineffective.
      
DNA binding affinity (ΔTm) of the tested compounds did not correlate with either their anti-P.
      
Prodigiosin also could induce apoptosis of pancreatic cancer cells at low concentration and results in the fragmentation pattern of DNA.
      
All compounds studied are significantly active in the RNA-dependent DNA-polymerase (RDDP) assay, and were not toxic toward the Vero cell line.
      
Stability of DNA upon interaction with dimethyltin dichloride
      
Results showed that over the concentration range of 6-16 mM, Me2SnCl2 is a chemical denaturant and denatures the double-strand DNA in a three-state manner.
      
Ultraviolet (UV) melting curves of the DNA at 260 nm as well as the calorimetric measurements were used to estimate the binding constants (K), melting enthalpy (ΔH°m) and binding enthalpy (ΔH°b).
      
Furthermore, at low concentrations (up to 5 mM), Me2SnCl2 binds to the phosphate groups of DNA in an exothermic step and had no significant effect on double-strand DNA stability, confirmed by the fact that the Tm value did not change.
      
However, high (denaturing) concentrations of Me2SnCl2 (more than 9 mM) caused considerable destabilization of DNA associated with the formation of a partially unfolded intermediate at 13.6 mM of Me2SnCl2.
      
The formed intermediate showed a lower thermal transition temperature (Tm) by a magnitude of 10°C in relation to the native DNA.
      
Finally, a new correlation is introduced for interpretation of thermal denaturation behavior of calf thymus DNA over the whole range of ligand (Me2SnCl2) concentration (0-16 mM).
      
Newly obtained benzoxazole and benzimidazole derivatives (1-6) were synthesized in the presence of polyphosphoric acid (PPA) and 6 N HCl, respectively to detect their DNA-damaging activities.
      
Restriction Enzyme Pattern Analysis of Mycobacteria DNA by Capillary Electrophoresis with Laser-Induced Fluorescence Detection
      
A new method for rapidly detecting restriction enzyme patterns of Mycobacterium DNA using capillary electrophoresis with laser-induced fluorescence detection (CE-LIFD) was developed.
      
 

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