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Oxidative stress is considered a major contributor to etiology of both "normal" senescence and severe pathologies with serious public health implications.
      
However, any replacement among five conserved residues in the RNA-binding site of TL5, as well as of L25 resulted in serious destabilization or complete impossibility of complex formation.
      
Accounting for fluid compressibility creates serious difficulties in solving the problem of oscillations of a grid of thin, slightly curved profiles in a subsonic stream.
      
The problem is not self-similar and its exact solution, which involves working with partial differential equations, presents serious difficulties.
      
It is fully justified at present, when the imperfection of rheological models and methods of hydrodynamic calculation of flows of elastic fluids does not give reason to hope for the serious development of a two-dimensional description.
      
The indeterminacy in the values of the vibrational energy lost by air molecules during dissociation and recovered during recombination does not lead to serious errors in the macrocharacteristics of the flow.
      
Volatile compounds of radioactive iodine, including methyl iodide, are released into the environment in the cases of serious accidents at nuclear power plants.
      
The experimental data on the density and electrical resistivity of liquid zirconium are essential for simulation of the behavior of nuclear power plants in the case of a serious emergency.
      
The inclusion of the polydispersity of droplets and semitransparency of diesel fuel made possible a serious revision of the known estimates of the importance of thermal radiation.
      
The operators during whose duty serious control errors and preaccident situations were noted were examined.
      
In this study, ordinary spectrophotometry was limited for use because of the serious interference of excess reactant.
      
Methods for the electrochemical analysis of biological samples with the use of nanoparticles can be a serious addition to classical biochemical methods.
      
Moreover, nucleosomes can present a serious barrier for transcribing polymerases that dramatically decreases the rate of transcription and is probably regulated in vivo.
      
Although embryonic SCs are promising for medicine, there are serious limitations of their use in therapy in the near future.
      
Serious study and development in this area only began in the early 1990s.
      
Compilers are used for creating executable modules for programs written in high-level languages; therefore, the presence of errors in a compiler is a serious danger for the quality of the software developed with the use of this compiler.
      
Compilers are used for creating executable modules for programs written in high-level languages; therefore, the presence of errors in a compiler is a serious danger for the quality of the software developed with the use of this compiler.
      
More serious changes, such as pH decrease to 4.0, suppress the adaptation processes in the first medium and terminate them in the second one.
      
In the former case, serious disturbances in the localization of mitochondria appeared already from the middle of two-cell stage, long before the time corresponding to the 2nd cleavage division.
      
This process was proposed a long time ago by Kolotyrkin and co-workers, but their experimental results were subjected to serious criticism which is taken care of in the present paper.
      
 

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