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human bladder tumor
    Inhibition of human bladder tumor cell line EJ by adenovirus mediated over expression of human p27 KIP1
    Adp27~(KIP1)基因的过度表达对人膀胱癌细胞系EJ的抑制作用
    Construction of MDR human bladder tumor model in nude mice by gene transfer in vivo
    体内基因转移建立多药耐药性人膀胱癌裸鼠荷瘤模型
    Lethal effects of adenovirus-mediated CD-TK gene on human bladder tumor cell
    腺病毒介导的CD-TK融合基因联合GCV和/或5-Fc对人膀胱癌细胞的杀伤作用
    Lethal Effect of Adenovirus-mediated CD-TK Fusion Gene on Human Bladder Tumor Cells in Vitro and the Inhibition of the Tumor Growth in Vivo
    腺病毒介导的CD-TK融合基因联合GCV和/或5-Fc对人膀胱癌的治疗作用
    A human bladder tumor cell line resistant to adriamycin,BIU-87/ADM,has been established in vitro by the stepwise exposure of BIU-87 human bl adder cancer cell to increasing concentrations of the drug over a period of 8 months.
    为探讨肿瘤细胞耐药性,以人膀胱癌细胞株BIU-87为亲本,以递增阿霉素剂量的方法,历时8个月,成功地诱导建立了一株耐药细胞亚株BIU-87/ADM。
    Human bladder tumor cells(BT5637) were treated with HESW(200sw) alone or in combination with 10hydroxy camptothecinum(01μg/ml).
    采用200SW与0.1μg/ml10-羟基喜树碱单独或联合作用于人膀胱癌细胞(BT5637)。
    AIM: To increase the expressed level of a human-mouse chimeric antibody against human bladder tumor in dihydrofo-late reductase (DHFR) defective CHO cells(CHO/DHFR) via weakening the transcription of DHFR gene in the vector.
    目的:提高抗人膀胱癌人-鼠嵌合抗体在二氢叶酸还原酶缺陷的CHO细胞株(CHO/DHFR-)中表达的产量。
    Objective To evaluate the in vitro and in vivo function of anti human bladder tumor human mouse chimeric antibody ch BDI and its future clinical application.
    目的 鉴定抗人膀胱癌人 鼠嵌合抗体ch BDI在荷瘤鼠体内外功能 ,探讨其临床应用价值。
    The synergistic effects of high energy shock waves and 10-hydroxyl camptothecinum on human bladder tumor cell line in vetro
    HESW与羟基喜树碱对体外人膀胱癌细胞协同作用的研究
    Expression of transforming growth factors and epidermal growth factor receptor in human bladder tumor
    转化生长因子和表皮生长因子受体在人膀胱癌中的表达
    Preparation of doxorubicin-loaded nanoparticles and reversion of MRP mediated MDR of human bladder tumor cell line in vitro
    阿霉素纳米粒的制备及体外逆转人膀胱癌细胞多药耐药的实验研究
    Effect of antisense phosphorothioate oligonucleotide on activity of telomerase for human bladder tumor cell
    反义硫代寡核苷酸对人膀胱癌细胞端粒酶活性的影响
    The result showed that it is more difficult to express the anti-HCC complete antibody (HAb25) than to express chimeric antibody against human bladder tumor. In order to prove that certain antibodies could be expressed in these expression vectors constructed previously, we changed the anti-HCC complete antibody (HAb25) with chimeric antibody against human bladder tumor. Three expression vectors (pIRESdhfr-B, pIRESdhfr-BA and pDI-B2) were used in this research work.
    为了进一步验证构建的dhfr基因弱化的一系列载体能否有效实现全抗体的高表达,我们将新构建的一系列载体中的抗人肝细胞肝癌抗体基因替换为抗人膀胱癌全抗体基因,并选择了其中三种载体(即pIRESdhfr-B、pIRESdhfr-BA和pDI-B2)进行了系统的表达研究。
    The result showed that chimeric antibody against human bladder tumor could be constantly expressed in CHO cells by any of these three expression vectors with a positive ratio of 100% under selective condition (IMDM, 10% dialyzed serum without H and T).
    结果表明,此三种载体都能够有效实现抗人膀胱癌全抗体在CHOdhfr-细胞中的稳定表达,且在无H和T的筛选条件下,阳性率都为100%。
    We have studied the synergistic effects of HESW (electrohydraulically,generated by ESWL-III/2M type, 200sw)alone or in combination with 10-hydroxyl camptothecinum(0.1ug/ml) on human bladder tumor cell line(BT5637). The changes of celluar biological characteristics in each group were observed. When NESW was admlnistered alone,temporary inhibitation of tumor cell growth was observed.
    ESWL-Ⅲ/2M型液电碎石机产生的HESW(200SW)与10-羟基喜树碱(0.1μg/ml)单纯或联合作用体外人膀胱癌细胞(BT5637),观察各组癌细胞的细胞生物学特性变化。
    Human bladder tumor cell line (BT5637) was managed by HESW(high energy shock waves,electrohydrulically generated, ESSL-Ⅲ/2M type) alone or in combination with 10-hydroxy camptothecimun(an anti-tumor drug).
    利用国产液电碎石机(ESWL-Ⅲ/2M型)产生的高能冲击波和10-羟基喜树碱单纯或联合处理人膀胱癌细胞系(BT5637)。
    Immunonanospheres (BDI-1-HSA (ADR ) -NS) against human bladder tumor cell lines were constructed by covalently cross linking the monoclonal antibody BDI-1 with adriamycin loaded human. serum albumin nanospheres via hetero bifunctional crosslinker SPDP.
    人膀胱癌单克隆抗体BDI-1通过异型双功能交联剂SPDP与载阿霉素人血清白蛋白毫微球偶联,制备了免疫毫微球DBI-1-HSA(ADR)-NS。
    Objective: To construct anti human bladder tumor chimeric antibody eukaryotic expression vector, and express the antibody in eukaryotic cells.
    目的 :构建嵌合型抗人膀胱癌抗体的真核表达载体 ,并实现其真核表达。
    The expressed chimeric antibody had fairly good affinity against human bladder tumor cells.
    初步的功能鉴定表明抗人膀胱癌人 鼠嵌合抗体具有较好的特异性和亲合力。
    Conclusion ch BDI has fairly good function against human bladder tumor both in vitro and in vivo, and is promising in clinical use.
    结论 抗人膀胱癌人 鼠嵌合抗体ch BDI在体内、体外均具有良好的与人膀胱癌组织的结合活性 ,有较理想的临床应用前景
 

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