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apoptosis (
    APOPTOSIS(PCD) OF MURINE THYMOCYTES INDUCED BY ANTI-CD4 McAb IN VIVO
    CD4单克隆抗体在体内诱导小鼠胸腺细胞凋亡
    Results Desflurane enhanced expression of HO-1-mRNA, PERK1/2 and PP90RSK, meanwhile increased neuron viability and decreased neuron apoptosis(vs group C and I/R,P<0.01).
    D12组PERK1/2和PP90RSK蛋白表达增加,HO-1-mRNA表达增加,神经元存活率增加、神经元凋亡率降低(vsI/R组或D6组,P<0.01或P<0.05)。
    Compared with normal or SODN group, ASODN group possessed significant traits of lower tumor weight, higher IR, lower expression of survivin and VEGF protein, and higher apoptosis (each P<0.01), but no significant difference was found between normal group and SODN group in these traits (each P>0.05).
    此外,相对于正常组和SODN组,ASODN组具有显著的survivin和VEGF低表达、高凋亡、低瘤重和高抑瘤率特点(各P<0.01),而正常组与SODN组间未见上述各特点的统计学差异。
    And compared with the normal control group, the three groups all showed significant apoptosis (P <0.05) when peritoneal mesothelial cells were treated with 1.5% glucose for 24 hours, 72 hours, 120 hours respectively.
    与正常对照组比较,1.5%葡萄糖分别作用于腹膜间皮细胞24h、72h、120h,各时间组均出现明显的凋亡(P<0.05)。
    Compared with controls, at 48 h following transfection cell cycle was redistributed again which the percentage of sub-G0/G1 phase (58.48±6.17)% increased while that of sub-S phase (25.11±2.70)% decreased,and the percentage of early apoptosis (8.95±0.88)% increased;
    与对照组比,转染48h细胞周期重新分布,G0/G1期(58.48±6.17)%的明显上升,S期(27.72±5.10)%下降; 细胞早期凋亡率(8.95±0.88)%上升;
    B-RAF-siRNA inhibited BGC823 cell prolifera- tion and induced apoptosis (P < 0.01).
    促进胃癌BGC823细胞的凋亡(P<0.01)。
    t-test was used for statisticalanalysis Resullts pingyangmycin could induce Tca8113 cells apoptosis(8.74±0.65%),p65 was activated and translocated from cytoplasm intonucleus during apoptosis,and after 24h p65 translocated back into cytoplasm and became inactive.
    结果平阳霉素能诱导Tca8113细胞凋亡(凋亡率8.74±0.65%),免疫组化显示:在凋亡发生时,p65信号蛋白由非活化状态转变为活化状态,从胞浆中穿过核膜进入细胞核。 24h 后p65信号蛋白由胞核回到胞浆,并成为非活化状态。
    ISOLATION OF A GENE RELATED TO TRICHOSANTHIN- INDUCED APOPTOSIS(GRETA)
    天花粉蛋白诱导的凋亡相关基因(GRETA)的分离
    MAPKs are the cytoplasmic signaling molecular family that can converge and transduct extracellular signals into cell nucleus for mediating the cell biological responses such as growth and proliferation(by the subfamily p44/p42 MAPK) and apoptosis(by p38MAPK).
    MAPKs是存在于细胞胞浆的蛋白激酶超家族(主要亚家族为p44/p42MAPK和p38MAPK),是细胞外信号诱导的生长增殖反应和凋亡反应的信号转导通路中具有汇聚功能和越核膜转导作用的关键信号分子。
    (2) EA could significantly reduce the number of myocardial cell apoptosis (p<0.01, p<0.05).
    (2)电针可显著降低缺血再灌注损伤家兔心肌凋亡细胞数量(P<0.01,P<0.05)。
    Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) was first cloned by Chicheportiche, et al. in 1997. It was named as TNF ligand superfamily member 12(TNFSF12) .
    肿瘤坏死因子样弱凋亡因子(TNF-like weak inducer of apoptosis,TWEAK)是1997年由Chicheportiche等发现的一种新的TNF超家族成员,按发现时间次序被命名为肿瘤坏死因子配体超家族成员12(TNFSF12),它是一种Ⅱ型跨膜蛋白。
    Survivin encode 142 amino acids, 16.5 kDa intracellular protein that belongs to the inhibitor of apoptosis (IAP) gene family.
    survivin定位于17q25,是一个凋亡抑制基因,属于IAP家族。 它编码142氨基酸贱基16.5KD的胞浆蛋白。
    alteration of the genes and the proteins involved into the control of apoptosis (especially P53 and Bcl-2);
    控制凋亡的基因和蛋白的改变,如P53和Bcl-2;
    When the machinery of apoptosis is improperly regulated, it will result in tumorigenesis and tumor progression. Survivin has recently been identified as a novel inhibitor of apoptosis (IAP).
    Survivin是新近发现的一种凋亡抑制基因,其表达的蛋白是凋亡抑制蛋白(inhibitor of apoptosis protein,IAP)家族的新成员。
    3. Ad-ASmyc, Ad-AScyclin D1 and Ad-RA538 had obvious inhibiting effects on the growth of the two hepatocellular carcinoma cell lines, besides, they induced tumor-cell-specific cell cycle arrest and apoptosis(cell cycle arrest and apoptosis took place simultaneously), while the 2BS cells were not affected.
    3.Ad-Asmyc、Ad-AscyclinD1、Ad-RA538对两种人肝细胞癌细胞系具有明显的增殖抑制和诱导凋亡作用,而作为正常细胞的2BS细胞的生长并未受到影响,说明三种重组腺病毒的治疗作用具有肿瘤细胞特异性;
    The x-linked inhibitor of apoptosis (XIAP), as the most potent one of inhibitor of apoptosis (IAP) families, up-regulating in many cancer tissues and cells, is thought an important factor contributed to carcinoma proliferation, transformation and chemoresistance.
    X-连锁的凋亡抑制蛋白(X-linked inhibitor of apoptosis protein,XIAP)参与了多种恶性肿瘤的增殖与转化,并与肿瘤的化疗耐药性密切相关,是凋亡抑制蛋白家族中对凋亡抑制作用最强的一种。
    1. The neutrophil counts increased significantly during CPB and reached its peak value (12.76+3.90xl09/L, p<0.01) in the first morning postopertively. The neutrophil counts correlated negatively with the rate of neutrophil apoptosis (r=-0.4528,p<0.05).
    1.中性粒细胞数量在CPB期间明显升高,并持续上升至术后第1d晨达峰值(12.76±3.90×10~9/L,p<0.01),与CPB前比较差异有非常显著性,其停CPB后30min值与PMN凋亡率呈负相关(r=-0.4528,p<0.05)。
    BQ123 (selective antagonist for ET receptor A, 1 mM) and BQ788 (selective antagonist for ET receptor B, ImM) partially blocked the effect of ET-1 inducing neuron apoptosis (P<0.01), respectively.
    BQ123和BQ788分别部分阻断了ET-1诱导神经元凋亡的作用(P<0.01),但阻断效果不完全。
    While inhibitor of apoptosis protein (lAPs) family is the unique intrinsic apoptosis inhibitor through inhibiting caspase activation in mammals. Among lAPs, X-chromosome-linked inhibitor of apoptosis (XIAP) is the most potent and versatile regulator of apoptosis which blocks not only the activation of the initiator caspases (caspase-9) but also the effector caspase (caspase-3, -7).
    IAPs(inhibitorof apoptosis)家族是哺乳动物体内唯一的内源性凋亡抑制剂家族,其中X—连锁的凋亡抑制剂(X-linked inhibitor of apoptosis,XIAP)不但能抑制调控Caspase(Caspase-9)的活化,还能抑制效应Caspase(Caspase-3、-7)的活化,因而具有全面抗凋亡作用。
    3. During the progression of cataract, the expression of HSP70 was positively correlated with that of PCNA (P<0. 01) , but was negatively correlated with the LECs apoptosis (P<0. 01) .
    3.在白内障发展过程中,HSP70与PCNA的表达变化呈正相关(P<0.01),HSP70与凋亡率的变化呈负相关(P<0.01)。
 

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