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laryngeal squamous cell carcinomas
    Transcriptomic Abnormalities Associated with Recurrence and Metastasis in Laryngeal Squamous Cell Carcinomas
    转录组异常改变与喉鳞癌复发转移的研究
    Conclusion PI3K and p-Akt express highly in laryngeal squamous cell carcinomas, which is related to the pathological differentiation and pathogenesis of the tumor.
    结论喉鳞癌存在PI3K和Akt蛋白的异常表达并与癌细胞的病理分级关系密切,PI3K/Akt途径的异常活化可能在喉鳞状细胞癌发生过程中起重要作用。
    The expression of CDK_4, Cyclin D_1, P~(16) proteins in 105 patients with laryngeal squamous cell carcinomas
    喉鳞癌组织中CDK_4、cyclin D_1、P~(16)蛋白表达
    HPV Infection and p53 Gene Mutations in Laryngeal Squamous Cell Carcinomas
    喉鳞癌中人乳头瘤病毒感染与p53基因突变的关系
    Factoral Analysis Related to Primary Recurrence of Laryngeal Squamous Cell Carcinomas after Treatment
    喉鳞癌治疗后原发灶复发的相关因素分析
    Expression of Telomerase Reverse Transcriptase and Its Relationship with Expression of c-myc in Laryngeal Squamous Cell Carcinomas
    端粒酶催化亚单位与c-myc在喉鳞癌组织中的表达及意义
    Objective: To explore the abnormalities associated with recurrence and metastasis in laryngeal squamous cell carcinomas (SCC), using comparative expressed sequence hybridization (CESH).
    目的:应用比较表达序列杂交(Comparative Expression SequenceHybridization,CESH)技术分析喉鳞癌组织的转录组异常改变,揭示这些异常改变与喉鳞癌复发转移的关系。
    Until recently, the joint detection of P53, Bcl-2 Bax oncoprotein and the relation among the expression of P53,Bcl-2 and Bax in laryngeal squamous cell carcinomas have not been reported.
    目前,同时观察P53、Bcl-2和Bax三种基因蛋白产物在喉鳞癌癌变过程中的表达及相互关系的研究,国内外尚未见报道。 本研究采用免疫组化S-P技州州I人学问002)顾1学位论上 调厂川队u;
    1. To investigate the expression and the clinical significance of proto-oncogene cerbB-2 proteins pl85 、 adhesion molecules CD44v6 and matrix metalloproteinase mmp—2 in laryngeal squamous cell carcinomas (LSCC) and the lymphoid metastasis of LSCC.
    1.研究P185、CD44v6和mmp-2在喉鳞癌、手术安全缘、声带息肉中的表达,探讨三者与喉癌发生、发展及淋巴结转移的关系。
    Background & Objective: This study was designed to investigate the factors associated with the primary recurrence in laryngeal squamous cell carcinomas after treatment.
    背景与目的:分析与喉鳞癌治疗后原发灶复发相关的因素。
    Methods: An immunohistochemical study was performed using the polyclonal antibody against nm23/NDPK and three monoclonal antibodies against human typeⅣcollagen (CTⅣ),laminin (LN) and fibronectin (FN) to observe the expression and the distribution of nm23/NDPK and extracellular matrix (ECM) antigens in 72 cases of supraglottic laryngeal squamous cell carcinomas,and to assess the relationship with the metastasis of cervical lymph node.
    方法:分别应用nm23/NDPK多克隆抗体、抗Ⅳ型胶原纤维(typeIVcollagen,CTⅣ)单克隆抗体、抗层黏连蛋白(laminin,LN)单克隆抗体、抗纤维连接蛋白(fibronectin,FN)单克隆抗体以链霉素亲生物素—过氧化酶免疫组织化学法观察nm23/NDPK和这3种抗原在72例声门上型喉鳞癌中的表达与分布及其与颈淋巴结转移的关系。
    Expression of VEGF in laryngeal squamous cell carcinomas and its clinical significance
    喉鳞癌血管内皮生长因子的表达及其临床意义
    Part I Expression profiles of apoptotic regulators in laryngealsquamous cell carcinomasObjective To screen for the differentially expressed apoptotic genes in laryngeal squamous cell carcinomas using QEArray Q Series Human Apoptosis GeneArray hybridization methodMethods Total RNA of laryngeal carcinoma tissue and its adjacent normal laryngeal tissue was abstracted, cDNA probe was synthesized and labelled with biotin using Ampolablaleing-LRP method .
    目的 了解凋亡相关基因在喉鳞状细胞癌中的表达概况,探寻其在喉鳞癌及正常喉组织中的表达差异及意义。 方法 提取喉鳞癌及癌旁正常喉组织的总RNA,采用Ampolablaleing-LRP方法,分别将上述提取的RNA合成生物素标记的cDNA探针。
    The discovery about the apoptotic genes may yield some clues on the oncogenic mechanism of laryngeal cancer. Part II Expression of Bak、 Bax and Survivin 、 Bcl-2 in laryngeal squamous cell carcinomas
    方法 采用免疫组织化学染色方法检测45例原发性喉鳞癌(primary laryngeal squanmous cell carcinoma,PLSCC)及10例正常喉黏膜(normal laryngeal tissues,NLT)石蜡标本组织中Bak、Bax和Bcl-2、Survivin蛋白的表达。
    The testosterone, progestrone and estradiol receptors (TR, PR, ER) were analyzed with direct fluorescent histochemistry in 33 laryngeal squamous cell carcinomas and their neighbering tissues.
    用荧光组化法测定33例喉鳞癌及癌旁组织的睾丸酮、孕酮和雌二醇受体。
    The results showed that 25(57%) of 44 laryngeal squamous cell carcinomas(LSCC) were positive,4 of 20 transitional mu-cosas were also positive,20 cases of the end of the sample and 16 cases of benign lesion were all negative.
    结果显示:25例(57%)喉鳞癌呈阳性反应,4例(20%)距肿瘤边缘<0.5cm的喉癌旁组织呈弱阳性反应,20例距肿瘤边缘>2cm的喉癌旁组织及16例声带息肉均为阴性。
    Using the monoclonal antibodies PC 10 and DO-1, the expression and clinical significance of proliferating cell nuclear antigen (PCNA) and p53 oncoprotein were investigated by Labelled Streptavidin Biotin (LSAB) immunohistochemical method in 30 cases of laryngeal squamous cell carcinomas (LSCC) and 10 cases of polyp of vocal cord (PVC) The results were: 1) PCNA-positive rate was 100% (PCNA-LIs 16%~92%) and 11 cases showed strong positive rate in LSCCs, but only 4 of the 10 cases of PVC showed weaker PCNA-positive rate (PCNA-LIs<10%) The expression of PCNA in LSCCs was significantly higher than that in PVCs ( P<0 05) ;
    本文以LSAB免疫组化方法,用单克隆抗体PC10和DO-1对30例喉鳞癌及10例对照组(声带息肉)的增殖细胞核抗原(PCNA)与p53蛋白表达进行研究,探讨其生物学意义。 结果发现:1)喉鳞癌组织PCNA阳性表达率为100%(PCNA-LIs16%~92%),强阳性率为367%(11/30),对照组6例阴性,4例弱阳性表达(PCNA-LIs<10%),试验组阳性表达率及表达程度明显高于对照组(P<005)。
    The aim of our study was to analyze the correlation between tumor-cell kinectics and p53 protein expression in 11 cases of simple hyperplasia of epithelium(SHE),32 cases of atypical hyperplasia of epithelium(AHE) and 42 cases of laryngeal squamous cell carcinomas(LSCC) by means of immunohistochemical technique.
    为探讨喉上皮癌前病变及癌组织 p53蛋白的表达与细胞增殖活性的关系 ,应用免疫组化技术对 11例喉上皮单纯性增生 (SHE)、32例非典型性增生 (AHE)及 4 2例喉鳞癌 (LSCC)进行研究。
    Objective:In order to investigate the telomerase activity and its relationship with the overexpression of cyclin D 1 protein in laryngeal squamous cell carcinomas ( LSCC).
    目的 :了解喉鳞癌端粒酶活性的表达情况及其与细胞周期蛋白D1(cyclinD1)过度表达的关系。
    Objective:To investigate the expression and the protective significance of extracellular matrix (ECM) in laryngeal squamous cell carcinomas(LSCC).
    目的 :探讨细胞外基质 (ECM )抗原的表达及其在声门上型喉鳞癌中的屏障意义。
 

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