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    EXPERIMENTAL STUDY ON THE SPECIFIC IMMUNOLOGICAL TOLERANCE TO CARDIAC ALLOGRAFT——NDUCTION OF SPECIFIC HYPOIMMUNOLOGICAL RESPONSE TO RAT HEART ALLOGRAFTS BY DONOR SPLEEN CELLS
    移植心脏特异性免疫耐受的实验研究——供体脾细胞诱导大鼠移植心脏特异性免疫低反应的研究
    ①The mean survival time of cardiac allograft in the splenocytes+cyclophosphamide group and splenocytes preconditioning group was longer than the control group and cyclophosphamide group [(30.17±2.79), (30.67±3.44); (5.29±0.76), (5.50±0.55) days, P < 0.01].
    ①脾细胞+环磷酰胺组、脾细胞预处理组受体大鼠移植心脏的存活时间均长于未作耐受诱导的对照组和环磷酰胺组[(30.17±2.79,30.67±3.44;5.29±0.76,5.50±0.55)d(P<0.01)]。
    Experimental study of myocardial fibrosis in cardiac allograft in rat
    大鼠移植心脏心肌纤维化的实验研究
    The effect of apoptosis in rat cardiac allograft treated with CsA
    CsA对大鼠移植心脏细胞凋亡的影响
    Long-term observation of cardiac allograft survival in rats
    大鼠移植心脏存活的长期观察
    Effects of cyclosporin A pretreatment on expressions of tumor necrosis factorα and myeloperoxidase and in rat cardiac allografts during ischemia-reperfusion
    环孢菌素A预处理对大鼠移植心脏缺血再灌注时心肌TNFα、MPO的影响
    Experimental Study of Tetrandrine on Chronic Rejection in Heterotopic Heart Transplantation of Rat
    粉防己碱治疗大鼠移植心脏慢性排斥的实验研究
    Effect of sulfasalazine on expression of inteleukin-1 beta and intercellular adhesion molecule-1 in acute rejection of rat heart transplantation
    柳氮磺胺嘧啶对大鼠移植心脏心肌白细胞介素-1β和细胞间黏附分子-1表达的影响
    Effect of Tranforming Growth Factor-β_2 on Chronic Rejection of Rat Heart Transplantation Treated with Tetrandrine
    转化生长因子-β_2在粉防己碱对抗大鼠移植心脏慢性排斥中的作用
    Transforming growth factor β1gene-modified donor spleen cell transfusion induced allo-heart tolerance in rats
    输注TGF-β1基因修饰的供体脾细胞诱导同种大鼠移植心脏耐受的实验研究
    Effect of RDP1258 on survival of rat cardiac allograft
    HLA衍生肽RDP1258延长大鼠移植心脏存活时间
    Survival time of heart allografts in rats can be prolonged by administration of donor apoptotic bone marrow cells via portal vein before transplantation
    门静脉预输注供者凋亡骨髓细胞延长大鼠移植心脏的存活时间
    Protective effect of cobra venom factor on ischemia/refusion injury of cardiac transplantation in inbred rats
    CVF在大鼠移植心脏缺血再灌注损伤中的保护作用研究
    Effect of RDP1258 on Function of Lymphocyte and Survival of Rat Cardiac Allograft
    RDP1258对淋巴细胞功能及大鼠移植心脏存活时间的影响
    The transplanted hearts in rats who had been injected liverhomogenate filtrate (38.05±17.07d) beat longer than the control group(9.45±2.01d), their hemorrhage and necroses were lessened, with lessdeposition of IgM and IgG.
    肝匀浆提取液组大鼠移植心脏存活时间(38.05±17.07d)明显长于对照组(9.45±2.01d),心肌出血、坏死程度更轻,心肌组织内IgM、IgG 沉积更少。
    Result The mean survival times (MST) of cardiac allograft were 30.17±2.79d in the group injected splenocytes during the operation, and were 30.67±3.44d in the group injected splenocytes before operation.
    结果大鼠移植心脏的平均存活时间在术中输注脾细胞并使用单剂量环磷酰胺注射处理组为30.17±2.79d,在术前输注脾细胞诱导组为30.67±3.44d,二者均比没有诱导耐受的对照组延长(P<0.01);
    The model of transplantation rat heart into abdominal cavity was established.
    建立大鼠心脏移植模型 ,观察不同组大鼠移植心脏存活时间。
    Perioperative administration of RDP1258 in combination with CsA can significantly prolong survival of rat cardiac allograft.
    结论RDP1258能抑制急性排斥反应,围手术期给予RDP1258和CsA,能够明显延长大鼠移植心脏存活时间。
    Results: The mean survival of cardiac allografts was 19.37±2.93 days in McAb-25 group, 19.13±2.25 days in McAb-50 group,but 8.75±1.28 days in NS group(P<0.01). The lymphocytes proliferation and levels of IL-2 produced by rat splenic lymphocytes in both McAb groups significantly decreased(P<0.01).
    结果:受体体内短期应用DC McAb,McAb-25组大鼠移植心脏存活时间为(19.37±2.93)d,McAb-50组为(19.13±2.25)d,而生理盐水对照组(NS组)为(8.75±1.28)d(P均<0.01);
    ①The apoptotic index in the three experimental groups was significantly lower than that in the control group (8.06±0.70,6.63±0.52,3.12±0.45,12.07±1.32,P < 0.05), especially in the FDP plus CsA group (P < 0.01).
    ①1,6-二磷酸果糖组、环孢菌素A组、1,6-二磷酸果糖+环孢菌素A组大鼠移植心脏心室肌细胞凋亡指数较对照组明显降低(分别为8.06±0.70,6.63±0.52,3.12±0.45,12.07±1.32,P<0.05),1,6-二磷酸果糖+环孢菌素A组降低尤其明显(P<0.01)。
 

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