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squamous carcinoma of the cervix
    Objective To explore the expressions of PTEN and P53 protein in the squamous carcinoma of the cervix and its relationships with occurrence and development of the squamous carcinoma of the cervix.
    目的探讨宫颈鳞癌组织中PTEN和P53蛋白表达及其与宫颈癌发生发展的关系。
    Results The positive rates of expressions of PTEN and P53 were 40%(20/50),62%(31/50)respectively in the 50 cases of the squamous carcinoma of the cervix;
    结果50例宫颈鳞癌组织中20例PTEN阳性表达占40%(20/50),31例呈P53阳性表达占62%(31/50);
    Objective To explore the expression of MDM2 and P53 protein in the squamous carcinoma of the cervix and its relationships,and explore the mechanisms of occurrence and development of the squamous carcinoma of the cervix.
    目的探讨MDM2与P53蛋白在宫颈鳞癌中的表达及相关性,进一步探讨宫颈鳞癌的发生和发展机制。
    Results The positive expression rated of MDM2 protein in the squamous carcinoma of the cervix,atypical hyperplasia tissues of tumor-adjacent normal mucosa of uterine cervix were lower in turn,furthermore the positive expression rate of MDM2 protein in the carcinoma tissues is compared with that in the propotional adjacent tissues and normal mucosa tissues from each other,there is statistical significance(P<0.05).
    结果宫颈鳞癌组织、癌旁非典型增生组织与正常宫颈黏膜组织中MDM2蛋白阳性表达率依次降低,且癌组织、癌旁非典型增生组织及正常宫颈黏膜组织中MDM2蛋白表达间相比,差异有统计学意义(P<0.05)。
    The positive expression rates of P53 protein in the squamous carcinoma of the cervix,atypical hyperplasia tissues of tumor-adjacent normal mucosa of uterine cervix were lower in turn,furthermore the positive expression rate of P53 protein in the carcinoma tissues is compared with that in the propotional adjacent tissues and normal mucosa tissues from each other,there is statistical significance(P<0.05).
    宫颈鳞癌组织、癌旁非典型增生组织与正常宫颈黏膜组织中P53蛋白阳性表达率依次降低,癌组织、癌旁非典型增生组织及正常宫颈黏膜组织中P53蛋白表达间相比,差异有统计学意义(P<0.05)。
    Expressions and Significance of p16~(INK4A) and p14~(ARF) Proteins in Squamous Carcinoma of the Cervix
    p16~(INK4A)、P14~(ARF)蛋白在宫颈鳞癌中的表达及意义
    The expression of KAI1/CD82 and correlation with lymphonode metastasis in human squamous carcinoma of the cervix
    KAI1/CD82在宫颈鳞癌组织中的表达及其与淋巴结转移的关系
    Expression of MDM2 and P53 in the squamous carcinoma of the cervix and its relationships
    MDM2与P53在宫颈鳞癌中的表达及相关性研究
    Objective:To study the expressions and clinical significances of p16INK4A and p14ARF proteins in squamous carcinoma of the cervix(SCC),cervical intraepithelial neoplasia(CIN) and normal cervix samples.
    目的:研究p16INK4A和p14ARF蛋白在宫颈鳞癌(SCC)、宫颈上皮内瘤样病变(CIN)及正常宫颈组织标本中的表达特征和临床意义。
    BACKGROUND &OBJECTIVE: The preoperative diagnosis and management of stage ⅠA1 squamous carcinoma of the cervix remains a controversial subject. The aim of this study was to discuss diagnosis and appropriate management options of this disease.
    背景与目的:宫颈鳞癌ⅠA1期术前诊断和处理仍有争议,本研究旨在探讨ⅠA1期宫颈鳞癌诊断和处理的恰当方式。
    METHODS: Clinical data and pathological materials of 30 patients with stage ⅠA1 squamous carcinoma of the cervix, who were treated in Cancer Hospital, Chinese Academy of Medical Science, Peking Union Medical College between 1992 to 2001, were reviewed.
    方法:回顾分析我院1992~2001年收治的30例宫颈鳞癌ⅠA1期患者的临床和病理资料。
    Objective:To study the expression of KAI1/CD82 and its correlation with lymphonode metastasis in human invasive squamous carcinoma of the cervix.
    目的:探讨KAI1/CD82蛋白在宫颈鳞癌中的表达及其与宫颈癌淋巴结转移的关系。
    Methods: The expression of KAI1/CD82 was examined by immunohistochemical S-P method in 10 normal cervical tissues, 15 atypical hyperplasic of cervical epithelia tissues and 64 casses of squamous carcinoma of the cervix. We analyzed statistically the correlation between the immunohistochemical results and the clinicopathological features.
    方法:采用免疫组化S-P法检测KAI1/CD82在10例正常宫颈组织、15例不典型增生宫颈组织及64例宫颈鳞癌组织中的表达,分析表达结果与临床病理特征的关系。
    Conclusion: The lowexpression of KAI1/CD82 is significantly correlated with lymphonode metastasis, which can be used as a useful marker to predict lymphonode metastasis in human invasive squamous carcinoma of the cervix.
    结论:宫颈鳞癌中KAI1/CD82表达下调与淋巴结转移显著相关,可用来预测淋巴结的转移状况。
    Through statistic test,the positive expression rates of both invasive squamous carcinoma of the cervix were significantly lower in normal cervical tissue and CIN(P<0.05),while it was of no statistical significance between the latter two(P>0.05).
    在宫颈鳞癌中的表达率明显低于正常组织和不典型增生组织(P<0.05),而正常组织与宫颈不典型增生组织之间无显著性差异(P>0.05)。
    Methods A total of 24 patients with squamous carcinoma of the cervix (SCC) were treated with one cycle of cisplatin combined with hydroxycamptothecine, bleomycin regimen.
    方法对24例宫颈鳞癌进行1个疗程的以顺铂为主联合羟基喜树碱、博来霉素方案的新辅助化疗,以流式细胞术检测化疗前后的宫颈鳞癌组织中增殖细胞核抗原(PCNA)的表达;
 

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