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time-effect
    2. Formaldehyde could cause damage to embryonic development and there were dose-effect relationships and time-effect relationships in vitro.
    2.甲醛能影响体外器官形成期的昆明种小鼠胚胎生长发育,具有一定的胚胎毒性,呈剂量-效应关系和时间-效应关系,以神经管闭合不全、体位翻转不全、脑部形态异常、心脏发育迟缓等畸形为特征;
    Usingthis method, the GSH content of Rana nigromaculata tadpoles under different concentrationsof Na2SeO4 and Na2SeO3 were measured. The induce of selenate to the content of GSH intadpoles makes its variation has well time-effect and dose-effect relationship. Thesephenomena demonstrate that GSH is smart to the exposure of selenate, and therefore can beused as a sensitive index to selenate pollution.
    采用本法测定黑斑蛙蝌蚪在Na_2SeO_4和Na_2SeO_3不同浓度不同时间暴露染毒下机体GSH含量,硒盐对蝌蚪GSH的诱导使其变化具有较好的时间-效应及剂量-效应特征而表现应激反应提示蝌蚪GSH可对硒盐暴露作出快速灵敏的反应可作为监测硒污染的敏感生物标记。
    This method was used for testing the time-effect and dose-effect of the Co60 r-irradiation on the frequence of micronuclei of the lymphocytes in rat blood.
    应用这种方法测定了大鼠受Co~(60)-r射线照射的剂量-效应和时间-效应;
    This showed that PM2.5 could induce the DNA damage in alveolar and aggravate with increase of particle concentration and prolongation of toxicosis time, emerging dearly the dosage-effect and time-effect relations.
    由此可见,PM2.5可引起大鼠肺泡巨噬细胞 DNA 的损伤,且随着 PM2.5浓度的增加及染毒时间的延长而加剧,呈明确的剂量-效应关系和时间-效应关系.
    [Objective] To examine the dose/time-effect relationship of cytotoxicity of cadmium to human embryo nephridium cell (293 cell) and observe the effect of co-exposure to cadmium and zinc.
    [目的]分析镉对肾细胞毒作用的剂量-效应关系和时间-效应关系,并观察锌对镉所致损伤的保护作用。 [方法]实验采用人胚肾细胞(293细胞),设对照组、锌组、镉组、镉+锌组。
    A obvious dosage-effect and time-effect correktion were obtained, its half inhibitory concentrations (IC50) at 24,48 and 72 h were 10.66,2.43 and 0.46 μmol·L-1 ,respectively.
    结果As2O3可显著抑制U20S细胞生长,且剂量-效应和时间-效应关系显著(P<0.05),其24,钙和72 h的IC50值分别为10.66,2.43和0.46 μmol·L-1。
    Conclusion There are dose-effects and time-effect in the damage of spermatogenic functions in mice exposed to manganese.
    结论锰对小鼠生精功能的损伤呈一定的剂量-效应和时间-效应关系。
    【Methods】The time-effect relationship and concentration-effect relationship between celebrex and the expression of COX-2 mRNA and PGE_2 in bladder cancer T24 cell lines were studied by enzyme-linked immuno-absordent assay(ELISA) and reverse transcriptase polymerase chain reaction(RT-PCR).
    【方法】体外培养人膀胱癌细胞株T24细胞,应用逆转录聚合酶链反应(RT-PCR)和酶联免疫吸附测定(ELISA)方法,检测选择性COX-2抑制剂Celebrex与膀胱癌T24细胞株COX-2 mRNA和PGE2表达的时间-效应关系和剂量-效应关系。
    There were obvious dosage-effect and time-effect correlations (P<0.05). The half inhibitory concentrations (IC_ 50 ) at 24 h, 48 h and 72 h were 14.28 μmol/L, 13.63 μmol/L and 2.34 μmol/L, respectively.
    结果:(1)As2O3可显著抑制U251细胞生长,且剂量-效应和时间-效应关系显著(P<0·05),其24h、48h和72h的IC50值分别为14·28μmol/L、13·63μmol/L和2·34μmol/L。
    Results The condition of proliferation in curcumin groups decreased compared with the control group,there were dose-effect(10-500μM)and time-effect(12h,24h,48h,72h) relation in diferent curcumin groups.
    结果姜黄素各组较对照组增殖降低; 姜黄素各组,存在剂量-效应关系(10~500μM)和时间-效应关系(12h,24h,48h,72h)。
    Time-effect of microwave radiation on thymocytes in mice
    微波辐射对小鼠胸腺作用的时间-效应关系
    The results showed that: (1) there is no significant difference onicuring rate and time-effect among the three groups, (2) antibiotics showed effect to neonatal intestinal microflora, and the longer the antibiotics was used , the more significant the effect was;
    结果表明:(1)青霉素组、头孢组、联合用药组的治愈率以及时间-效应分析的结果无显著性差异; (2)使用抗生素对新生儿肠道菌群有影响,其影响随着抗生素使用时间的增加而增大;
    The time-effect and dose-effect relations could be induced for the expression of some protein spots upon irradiation, which might be a reflection of the response to the irradiation damages.
    γ射线照射后不同时间,某些蛋白的表达量显示出一定的时间-效应关系; 不同剂量γ射线照射后,某些蛋白的表达量具有一定的剂量-效应关系。
    Based on it dose-effect and time-effect relationships will be found. This result will do well to evaluate the toxicity degree of oils to marine at different time.
    在此基础上,建立了急性毒性试验的剂量-效应和时间-效应关系,此结果的发现对石油污染在不同时间对海洋生物的毒性影响评估很有意义。
    All the indexes of enzyme except SA presented a time-effect relationship.
    4.染氟组公鸡血浆氟含量较对照组明显升高(P<0.01),并呈一定的时间-效应关系。
    The exposing dose at level of 1/2 MED,the UDS level of basal cells was inceaseel significantly. For time-effect study,at the levl of 1/8 MED each day,the ch- ange of UDS is not significant.
    对紫外线照射的时间-效应关系研究表明,大于1/2MED的紫外线照射,程序外DNA合成持续增加,而1/8MED组则无明显改变。
    Compared with the control group,the content of iodine in thyroid in all fluorosed groups decreased,moreover,showed a significant dose-effect and time-effect correlation.
    各中毒组甲状腺中碘含量在整个实验期内均不同程序地低于对照组 ,呈明显的剂量 -效应和时间 -效应关系。
    Conclusions The rsults showed that pyridoxine had a certain inhibition on the growth hepatona H22 in vitro and does-effect and time-effect could be found.
    结论 吡哆醇对体外培养的H_(22)小鼠肝癌细胞系的生长具有抑制作用,且二者之间有剂量-效应关系和时间-效应趋势。
    The expression level of HSP70 was enhanced with the exposure days increasing and showed a good time-effect relationship.
    随着暴露天数的增加,肝脏组织和脑组织HSP70表达也显著增加,且存在着较好的时间-效应关系.
    ②Time-effect on cell proliferation: The A value was also increased with the culture time. After 5 days, the A value reached the peak, indicating the effect on proliferation was the most obvious. The A value began to decrease until the 7th day.
    ②对细胞增殖的时效作用:重组胰岛素生长因子对鼠成骨细胞的促增殖作用还存在时间-效应的关系,随着培养作用时间的延长,吸光度值增高,作用5d后,吸光度值达到最高峰,促增殖作用最为明显,到第7天后,吸光度值下降。
 

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