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    COLPOSCOPIC DIAGNOSIS IN CERVICAL DISEASE
    阴道镜下宫颈活检病理诊断准确度分析
    PATHOLOGICAL ANALYSIS OF 1246 CASES OF CERVICAL BIOPSY
    1246例子宫颈活检病理分析
    DETECTION AND CORRELATION OF HUMAN CYTOMEGALOVIRUS DNA AND C--MYC ONCOOGENE IN CHRONIC CERVICITIS
    慢性宫颈炎活检组织中人巨细胞病毒(HCMV)DNA和C—MYC癌基因的检测及相关性研究
    Detection of Human Papillomavirus DNA in Cervical Squamous Cell Carcinoma in Xinjiang Uygur Women
    新疆维吾尔族妇女子宫颈癌活检组织中人类乳头状瘤病毒DNA的检测
    Methods The 13 high-risk human papillomaviruses(HPV)in 102 chronic cervieitis patients with cer- vical contact bleeding sign were detected with hybrid captureⅡassay and biopsy was also performed using vaginoscopeo Results Eighty-two out of the 102 patients were positive for high risk human papilloviruses and of which 81 were histologically diagnosed as CINⅠor CINⅡ.
    方法对102例有宫颈接触性出血体征的慢性宫颈炎患者用杂交捕获二代试验(HC-Ⅱ)检测13种高危型HPV,并同时进行阴道镜下宫颈活检。 结果102例病例中,82例患者的13种高危型HPV检测结果为阳性,其中81例的病理学诊断为CINⅠ或CINⅡ。
    Method:Forty-five samples from patients with cervical cancer were as- sessed for HIF-1αand TRAIL-DR4 mRNA expression by in situ hybridization histochemistry (ISHH). Rusult:(1)HIF-1αmRNA was over expressed in 27 samples(60%).
    方法:收集2003年7月至2005年1月宫颈癌活检组织45例,用原位杂交组织化学法检测宫颈癌组织中HIF-1αmRNA及TRAIL-DR4mRNA水平。
    Results:In 545 cases of biopsy under colposcopy,there were 10 cases diagnosed as cervical carcinom and 77 cases diaqnosed as CIN,both came to 87 accouting for 16.0%;
    结果:545例阴道镜下活检诊断宫颈癌10例、CIN77例,共87例占16.0%;
    Methods Gross,microscopic changes of biopsies and total hysterectomies were analyzed in 10 cases of cervical MDA and immunohistochemical staining was used to detect the expression of CEA,p53,P16,Ki-67,CA125,ER, PR and HPV16/18 in 7 cases.
    方法对10例宫颈MDA的病理活检和/或全子宫切除标本进行巨检、光镜观察,其中7例行免疫组化染色测定CEAp、16、p53、Ki-67、CA125、ER、PR、HPV16/18等免疫表型。
    Methods The expression of C4d, C4c and routine immunohistochemical markers were studied in renal biopsy samples from 14 patients with PN using immunohistochemical staining and semi-quantitative scoring method.
    方法应用免疫组化方法检测14例PN肾活检组织中C4d、C4c及各种免疫球蛋白,半定量评分。
    Both tests were carried out independently and blindly. Results:The rate of the able detect for cytologic high grade squamous intraepithelial lesion(HSIL) and histologic CIN Ⅱ~Ⅲ was 71.43%, the rate of accuracy was 67.00%.
    结果细胞学鳞状上皮内高度病变与组织学活检的CINⅡ~CINⅢ检出率为71.43%,其准确率为67.00%;
    Methods Colposcopy,cervical biopsy and LEEP were performed on 191 patients with positive LCT results and 64 patients with negative LCT results but highly suspected clinically.
    方法对经液基细胞学检测系统(LCT)筛查阳性的病人191例及LCT筛查阴性但临床高度怀疑宫颈病变病人64例,行阴道镜检查和镜下活组织病理检查(活检)及LEEP治疗。
    Results Diagnosis was mainly confirmed by pathologic results. The diagnostic rate of combined diagnostic D&C(dilatation and curettage)and biopsy neoplasm of cervix was 60%(3/5).
    结果确诊主要依靠病理结果,术前诊断性刮宫结合宫腔镜,宫颈赘生物活检确诊率为60%(3/5);
    As well,endometrial biopsy revealed sensitivity were 96.3%,specificity 100%,positive predictive value 100% and negative predictive value 99%(ROC curve: 0.999).
    内膜活检的灵敏度和特异度分别为96.3%和100%,阳性预测值100%,阴性预测值99.0%(ROC曲线下面积:0.999)。
    Methods:There were 639 cases detected by TCT. In 619 ASCUS cases,346 underwent biopsy under colposcopy,and another 273 case recheck with TCT after three months of follow-up.
    方法:对639例TCT结果为ASCUS、AGUS进行分析总结,ASCUS619例,其中346例进行了阴道镜检查取活检病理诊断,另273例观察3月并对症治疗后复查TCT;
    Methods:42 cases of cervical carcinoma (stage Ⅱb more than) were treated with intervention 1~3 times. The clinical symptoms,tumor size,and pathological changes were observed.
    方法:选择经活检确诊为宫颈癌,临床分期Ⅱb以上患者42例,进行介入治疗1~3次后观察其临床症状及肿瘤大小、病理变化。
    Results There were 21 CINⅠ(included condyloma, 20.0%), 4 CINⅡ(3.8%), 1 CINⅢ(1.0%)and 79 chronic cervicitis(75. 2%)in the 105 biopsies of acetowhite epithelium.
    结果在105例醋酸白色上皮处行活检,CINⅠ级(包括宫颈湿疣)21例(20.0%), CINⅡ级4例(3.8%),CINⅢ级1例(1.0%),宫颈炎79例(75.2%)。
    Biopsy of the UCC was conducted before and during the treatment(group RT: after 10 Gy radiotherapy; group CRT: 10 Gy radiotherapy+{DDP+5-FU}×1 cycle). The samples obtained in the treatment were employed to determine apoptosis and the expression of Bax and Bcl-2 protein using TUNEL and immunohistochemical methods.
    在治疗前和治疗过程中(RT组:放疗10Gy后;CRT组:放疗10Gy+(DDP+5-FU)×1个周期)分别活检留取标本,用TUNEL法及免疫组化检测凋亡及Bax、Bcl-2的表达。
    Results: The of under-diagnosis rate of preoperative multiple punch biopsies was 8.0%(11.8% directed by the naked eye,2.2% with colposcopy),three cases of invasive cancer were missed.
    结果:术前宫颈多点活检的过低诊断率为8.0%(肉眼下多点活检11.8%、阴道镜下多点活检2.2%),漏诊浸润癌3例;
    Objective:To study the value of thin prep liquid-based cytology test(TCT),high-risk human papillomavirus (HPV-DNA) testing and colposcopy with biopsy in the early diagnosis of cervical lesions.
    目的:评价膜式液基薄层细胞学技术(thin prep liquid-based cytology test,TCT)、高危型人乳头状瘤病毒(high-risk human papillomavirus,HR-HPV)检测及阴道镜下宫颈活检对宫颈早期病变的诊断价值。
    Methods:Among 640 cases with abnormal cervical smear of TCT,320 cases were examined for HR-HPV by hybrid capture Ⅱ(HC-Ⅱ),372 cases of them received colposcopy with biopsy,272 cases received both HPV-DNA testing and colposcopy with biopsy.
    方法:640例TCT检查异常的患者中,320例应用杂交捕获技术(HC-Ⅱ)检测HR-HPV,372例进行阴道镜检查并取宫颈组织活检,同时行HR-HPV检测及阴道镜检查并取宫颈组织活检者272例。
 

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