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permeation quantity
    The permeability coefficient and cumulative permeation quantity(8 h) of DET sustained release cream were 0.0157 mg·cm-2·h-1 and 0.13 mg·cm-2,respectively.
    cm-. 2h-1,8 h累积渗透量为0.13 mg.
    The relation between temperature T and hydrocarbon solvent permeation quantity J is J=a 2e b 2T .
    烃类溶剂渗透量J随温度T的变化关系为:J=a2eb2T。
    The penetration of ketoprofen in the cataplasm through the BLAB/c mouse skin followed zero-order dynamics in 24 h. Its release equation in vitro was Q= 10. 196 t-7. 954 7 (r=0. 998 8). The cumulative permeation quantity in 24 h was 244. 70μg/cm2 through BLAB/c mouse skin in vitro.
    巴布剂中的酮洛芬24 h内以零级动力学经皮渗透,体外经皮释药方程为Q=10.196 t-7.954 7(r=0.998 8),24 h累积渗透量为244.70μg/cm2。
    The permeation enhancing multiple of 3% Azone group is the highest which is 8.1.CONCLUSION With the cumulative permeation quantity of ferulic acid as the index, 3% azone is more suitable to act as a permeation enhamer of CHP.
    结论 以阿魏酸累积渗透量为指标 ,选择 3%氮酮作为复方骨质增生贴剂的渗透促进剂更为适宜
    METHOD: Using improved Franz-type diffusion cel l and excised rabbit skin in vitro as transdermal barrier, the kinetics parame ters such as cumulative permeation quantity, permeation rate,permea tion lagged time and permeation coefficient were determ ined by RP-HPL C.
    方法 :采用改良的Franz扩散池 ,以离体新西兰家兔皮肤为透皮屏障 ,用高效液相色谱法测定不同透皮吸收促进剂对格列美脲累积渗透量、透皮吸收速率、透皮时滞和渗透系数等体外透皮吸收动力学参数的影响。
    RP-HPLC method of glimepiride in different permeation receptors was established in this article. Using improved Franz-type two-chamber diffusion cell, the in vitro permeation test of glimepiride ethanol solution via 5 kinds of isolated animal skin and in 6 kinds of permeation receptors was respectively carried out by adopting cumulative permeation quantity (Q), stability permeation rate(J) and permeation lagged time (t-(lag)) as permeability index.
    建立格列美脲体外透皮吸收的HPLC分析方法,采用改良Franz双室渗透扩散装置,以累积渗透量、透皮速率常数和透皮时滞为评价指标,研究了5种透皮吸收接受液和6种实验动物皮肤对格列美脲体外经皮渗透行为的影响。
    Method: Using improved Franz-type diffusion cell and excised big mouse skin in vitro as transdermal barrier, the kinetics parameters such as cumulative permeation quantity,permeation rate and permeation lagged time were determined by HPLC.
    方法:采用改良的Franz扩散池,以离体大鼠皮肤为透皮屏障,用高效液相色谱法测定不同透皮吸收促进剂对高乌甲素凝胶的累积渗透量、透皮吸收速率、透皮时滞等体外透皮吸收动力学参数的影响。
    The samples from the receptor solution were assayed by HPLC. Results: Azone could significantly enhance the percutaneous permeation of buspirone, and optimal transdermal constant of buspirone was reached when the 2 percent of azone was in the patch. The kinetic equation through male mice skin was Q=65.1031+9.408, and the accumulative permeation quantity of the buspiron patch was 143.036μg and 226.618μg at the 4h and 10h, respectively.
    结果:氮酮对丁螺环酮有明显的促渗透效果,但其渗透速率并不随着氮酮浓度的增大而增大,而是在氮酮含量为2%时有一最佳值,渗透速率常数为65.103g·cm~(-2)·h~(-1/2),4和10h的累积渗透量分别为143.036和226.618μg。
    METHODS Using improved Franz-type diffusion cell and mouse skin in vitro as transdermal barrier,the concentration of methyltestosterone in different kind and concentration enhancers was determined by HPLC,then cumulative permeation quantity (Q) of methyltestosterone was calculated.
    方法:用改良的Franz透皮扩散池,以离体鼠皮为屏障,制备包含不同种类和浓度的促渗剂的甲睾酮乙醇溶液,高效液相色谱法测定甲睾酮累积渗透量及渗透速率。
    Methods: Sinomenine gel was prepared with carbopol 980 as base material. Using improved Franz-type diffusion cell and isolated rat skin as transdermal barrier,the cumulative permeation quantity of sinomenine was determined by HPLC method.
    方法:以卡波姆980为辅料制备青藤碱凝胶剂,采用改良Franz扩散池,以离体大鼠皮肤为透皮屏障,用HPLC法测定青藤碱的累积渗透量
    The samples were obtained from receiving solution after treatment of 10 min,20 min,30 min,40 min and 50 min, respectively. Detecting the content of mesaconitine, and calculate Q (accumulative permeation quantity) at each corresponding time.
    以含生药3 g/ml浓度的生川乌提取液作为释放液,生理盐水作为接受液。 各组分别于实验开始后10,20,30,40及50 min时从接受液中取样,根据已求得的Y-X标准曲线测定各取样液中新乌头碱的浓度以及各时间点(t,min)新乌头碱的累积渗透量(Q,μg/cm2)。
 

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