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    Results The results showed that the amount of 3H water was not obviously increased in those exposed to gasoline for 0.5,1 and 2 h( P >0.05),but the 3H water penetration amount through the skin increased linearly with the time.
    结果 连续接触溶剂汽油 0 .5、1、2h组的大鼠皮肤 ,氚水经皮渗透量有所增加 ,但与对照组相比无统计学差异。
    In the group exposed to gasoline 4 h,the 3H water penetration amount through the skin was significantly higher than that in the control group ( P <0.05).
    而接触溶剂汽油 4h组 ,氚水经皮渗透量在各采样时段 ,均明显高于对照组(P <0 .0 5 )。
    RESULTS:The application of electroporative pulse or iontophoresis obviously increased naproxen permeation. The cummulative quantity and flux of naproxen with electroporative pulse(exponentially decaying pulse,voltage=400V,pulse time=6.0ms,capacity=2.2μF,pulse number=100,pulse frequncy=20pulses·min -1 ) or iontophoresis (1mA·cm -2 ,6h)was larger than passive diffusion.
    结果 :外加电脉冲 (指数衰减型脉冲 ,脉冲幅度为 4 0 0V ,电容器电容为 2 .2 μF ,脉冲率为 2 0pulses·min- 1,脉冲宽度τ≈ 6.0ms)或离子导入 ( 1mA·cm- 2 ,6h)时 ,萘普生的渗透速率和累积渗透量均大于被动扩散。
    The permeation of aminophylline in the films through the mice skin followed zero-order kinetics. The permeation rate was 16.58 μg/cm 2·h .
    结果表明 ,氨茶碱膜剂以零级动力学经皮渗透 ,0~ 12h累积渗透量 44 .7% ,渗透速率 16 .5 8μg/cm2 ·h。
    The penetration equation of ciclopirox olamine film was Q = 63.1541 t - 60.7299 ( r = 0.9940 ). The cumulative release level in 8 h was 505.23 μg·cm -2 through rat skin in vitro.
    其体外透皮释药方程为Q =6 3 .15 41t- 6 0 .72 99(r =0 .9940 ) ,8h累积渗透量为 5 0 5 .2 3μg·cm-2 。
    Results: The penetrative amount of paeonol of Shangtong Tincture with 60%~80% alcohol concentration have a optimal value, the average rate is 0.010mg/cm 2·h.
    结果 :含醇量为 60 %~ 80 %的伤痛酊丹皮酚渗透量存在一极值 ,8h内平均渗透速率为 0 .0 1mg/cm2 ·h。
    RESULTS:The cumulative quantity and flux of naproxen were obviously increased by electroporation (exponentially decaying pulse, voltage=380V, pulse time=5.5ms, capacity=22μF, pulse number=100, pulse frequency=4pulses·min -1), azone or both.
    结果 :电穿孔 (指数衰减型脉冲 ,脉冲幅度为 380V ,电容器电容为2 2 μF ,脉冲率为 4pulses·min 1,脉冲宽度τ≈ 5 .5ms ,脉冲数 10 0个 )、月桂氮 艹卓 酮预处理皮肤或两者合用均可显著促进萘普生的渗透速率和累积渗透量
    Method: Transdermal speed constant and accumulative amount of 12 hours were used for the estimations of various reservior vehicles, and the supplement orthodox design was used to study the effect of pH, various proportion of IPA/Water/IPM, and drug concentration.
    方法 :以透皮吸收速率常数和 12h累积渗透量为考察指标 ,应用正交设计追加试验法 ,探讨不同比例组成的IPA/Water/IPM、药物浓度及 pH值对青蒿琥酯经皮渗透影响。
    The relationship between accumulative permeation and time was linear.
    两者的累积渗透量与时间呈良好的线性关系 ,为零级渗透。
    Results The penetration enhancing ratio of the three drugs was 7 9 fold, 41 8 fold and 2 8 fold, respectively.
    结果 焦谷氨酸油醇酯使 3种不同类型药物经皮渗透的累积渗透量有明显提高 ,增渗倍数分别为 7 9,41 8和 2 8。
    The steady cumulative amount ( Q ) of ketoprofen from permeation and metabolism was linear with time ( t ), the equation of ketoprofen formation was Q = -0 024 +0 120 t , the rate of ketoprofen formation was 0 120 μg·cm -2 ·h -1 . Methyl salicylate was partially metabolized to salicylic acid.
    水杨酸甲酯经皮渗透过程中部分被代谢为水杨酸 ,稳态时水杨酸甲酯累积渗透量Q与时间t回归的方程为Q =- 3 80 9+6 1 2 9t,渗透速率为 6 1 2 9μg·cm-2 ·h-1 ;
    METHODS Determined accumulated absorbed drug per unit area with 1% SLS,2% PG or 1%SLS+2%PG as absorption promoters by using a two-cell diffused pool with mouse skin as the barrier.
    方法 :用两室扩散池体外实验装置 ,以鼠皮为屏障 ,选用 1%SLS、2 %PG和 1%SLS +2 %PG为促渗剂 ,在各时间下测定氨氯地平的单位面积累积渗透量
    Linear relationship between accumulated per- meation of betmethasone and time was satisfactory( r =0.9979).
    倍他米松累积渗透量与时间呈良好的线性关系 (r=0 .9979)。
    Results:1%~5% menthol and 1%~5% azone markedly enhanced Q and k of 2% amlodipine gel(P<0.01),but 10%~30% propylene glycol decreased Q and k value of 2% amlodipine gel(P<0.01).
    结果 :1%~ 5 %薄荷脑、1%~ 5 %氮酮对 2 %氨氯地平凝胶的累积渗透量Q及渗透速率k均显著地提高 (P <0 0 1) ;
    RESULTS When the continuous time of iontophoresis was 15,30,45,60,90 and 120minute,the amount iontophoretic flux of tetracaine hydrochloride jel was 5.74,11.25,15.37, 20.97 ,28.82 and 36.96mg/cm 2 respectively.
    结果 离子导入持续时间为 15 ,30 ,4 5 ,6 0 ,90 ,12 0min时 ,稳态累积渗透量分别为 5 .74 ,11.2 5 ,15 .37,2 0 .97,2 8.82和 36 .96 μg/cm2 。
    The results show that porosity and mean pore diameter increase and density and compressive strength reduce with increase of PVA amount;
    结果表明:PVA的加入量增加使陶瓷膜管的孔隙率和孔半径增大、密度和耐压强度减小、孔径分布变宽,气体渗透量增大;
    The penetration of accumulation within 24 h and steady velocity of β-asarone in 20% ethanol were (352.624±87.049) μg/cm2, (18.902±4.840) μg/(cm2·h), respectively.
    β-细辛醚在 2 0 %乙醇中 ,2 4 h累积渗透量和稳态渗透速率分别为 (35 2 .6 2 4± 87.0 4 9) μg/ cm2、(18.90 2± 4 .84 0 ) μg/ (cm2· h)。
    The amount of permeated defibrase caused by anodal iontophoresis in pH 7.4 medium was (25±5)×10-14 mol·cm-2, which was higher than that of in pH 6.4 permeation medium [(15±4)×10-14 mol·cm-2].
    在pH 7 .4磷酸盐缓冲介质中,降纤酶阳极离子导入经皮渗透量为 ( 25±5)×10-14mol·cm-2高于pH6 4介质经皮渗透量[ (15±4)×10-14mol·cm-2 ]。
    SEM and XRD results indicate that the membranes were demse ZSM-5 zeolite layer,the permeability of H_2 through the membrane was up to 3.690×10~(-6) mol/(m~2·s·Pa),the ideal separating factor of H_2 to C_3H_8 was 25.625
    对膜进行单气体渗透量测试,膜的H2渗透量3.69×10-6mol/(m2·s·Pa),H2/C3H8的理想分离因子为25 6.
    Results showed that the membrane was extremely effective for the dehydration of isopropanol/water mixtures by pervaporation. At 323 K and 343 K, the separation factors and the fluxes were more than 10 000 at m(C_3H_8O)/m(H_2O)=95∶5 and 1.27 kg/(m~2·h) and 1.74 kg/(m~2·h), respectively.
    考察了A型分子筛膜的渗透汽化性能,结果表明,在温度为323K和343K下,当原料液中异丙醇的质量分数为95%时,其水/异丙醇分离系数都大于10000,渗透量分别为1.27kg/(m2·h)和1.74kg/(m2·h).
 

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