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    Results:The expression of c-fos in dysplasia and carcinoma were apparently higher compared with normal and hyperplasia (P<0.01), the positive staining grade was correlated with the pathologic grades (P<0.01);
    结果 :c -fos在异常增生上皮及鳞癌的表达与正常和单纯增生组相比明显提高 (P <0 .0 1) ,阳性染色等级随病理等级改变提高 (P <0 .0 1) ;
    Results The expression of c-fos in dysplasia and carcinoma were apparently higher compared with normal and hyperplasia(P<0.01), the positive staining grade was correlated with the pathologic grades(P<0.01);
    结果 c fos在异常增生上皮及鳞癌的表达与正常和单纯增生组相比明显提高 (P <0 0 1) ,阳性染色等级随病理等级改变提高 (P <0 0 1) ;
    Result: The expression of CDK 2 in dysplasia and carcinoma were apparently higher compared with normal and hyperplasiaIn(P< 0.01), the positive staining grade was correlated with the pathologic grades(P<0.01).
    结果 :CDK2 在异常增生上皮及鳞癌的表达与正常和单纯增生组相比明显提高 (P <0 .0 5 ) ,阳性染色等级随病理等级改变提高 (P <0 .0 5 )。
    With the increase of clinicopathological grades, Cyclin Dl expression increased accordingly. Positive rate and mean labeling index were significantly higher in malignant gliomas than in benign gliomas (P<0.05).
    CyelinDl的表达随病理等级的递增而增高,高恶性度组阳性率和标记指数明显高于低恶性度组(P<0.05)。
    OBJECTIVE:To investigate the expressions of cyclin D1 and cyclin E in human brain gliomas and their correlation with pathological grades.
    目的 :研究人脑胶质瘤中细胞周期素 (cyclin)D1和cyclinE的表达与肿瘤病理等级的关系。
    Methods The expression of cyclin E and proliferating cell nuclear antigen (PCNA) was detected by immunohistochemistry in 52 human brain gliomas and 8 normal brain tissues to observe their positive rates and the labeling indices in each WHO grade of human brain gliomas.
    方法 采用免疫组化方法检测 5 2例人脑胶质瘤和 8例正常脑组织标本中cyclinE和增殖细胞核抗原 (PCNA)的表达水平 ,观察并分析各病理等级中两者表达的阳性率和标记指数。
    The following variables were used as the study objects: gender, irradiation and chemotherapy experience, margin radiation dose, mean diameter, pathological grade, border definition of the tumor, on which the influence factors were determined by logistic regression model.
    以性别、有无普通放疗经过、有无化疗经过、边缘剂量、病灶的平均直径、病变的病理等级、影像学上有无相对较清楚的边界为治疗结果影响因素,判定标准以病灶缩小为有效,采用logistic回归模型,确定多因素条件下治疗结果的影响因素。
    Results Of the 48 cases, 32 (66.7%) showed effective responses. In logistic regression mode, mean diameter and pathological grade of astrocytoma were found to be the significant influence factors for tumor control.
    结果有效32例(66.7%),logistic回归模型分析表明:病理等级和病灶平均直径为与肿瘤控制有关的影响因素。
    Results Curative speed of defected regions of group A was faster than that of the other groups;
    结果 A组的皮肤创面愈合速度明显快于其它治疗组 ,并且在皮肤愈合的组织病理等级评分上优于B、C和D组。
    Hierarchical scores of histopathology on the specimens of Group A were also higher than that of the other groups.
    A组在皮肤愈合的组织病理等级评分上优于B、C组;
    Results The positive rate of HSP27 was 39.13% in normal mucosa, 40.91% in hyperplasia, and 54.55% in dysplasia. The positive staining grade was 65.52% in squamous cell carcinoma which was higher compared to the normal mucosa and hyperplasia. The positive staining grade was correlated with the pathologic grade with a marginal significance ( P = 0.056).
    结果HSP27 在正常粘膜表达的阳性率为39.13%,单纯增生上皮为40.91%,异常增生上皮为54.55%,阳性染色等级与正常粘膜相比有增强趋势,鳞癌组织为65.52%,与正常和单纯增生组相比明显提高,全部阳性染色等级有随病理等级提高趋势。
 

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