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    Schizophrenia And Humoral Medium
    精神分裂症与体液介质
    Schizophrenia treated with metoclopramide in 17 patients
    甲氧氯普胺治疗精神分裂症17例
    Results:The blood glucose level was higher in group clozapine than other two groups(P<0.01),but no changes in group chlorderazin and Risperidone before and after drug treatment(P>0.05).
    结果:氯氮平组的精神分裂症患者治疗后血糖较治疗前明显升高(P<0.01),氯丙嗪和利培酮组治疗后血糖无明显变化(P>0.05)。
    A preliminary study of efficacy of risperidone on treating schizophrenia and clinical application of PANSS
    维思通治疗精神分裂症疗效与PANSS应用的初步研究
    Meta-analysis of comparative study in treatment of negative symptom between risperidone and other antipsychotics.
    维思通与其它抗精神病药物治疗精神分裂症阴性症状对照研究的Meta分析
    Analysis of Antipsychotics Used for Schizophrenia in44Hospitals in Guangdong Province During the Pe-riod2000~2002
    2000年~2002年广东地区44家医院抗精神分裂症药物应用分析
    A positive correlation between SOD activity and total BPRS scores was found (r=0.588,P< 0.05).
    研究发现精神分裂症病人红细胞SOD活性改变与BPRS总分呈正相关(γ=0.588,P<0.05)。
    Results Compared with the normal persons,both the levels of serum LP0 and SOD were obvi. ously higher(P<0.05,P<0.01)and GPX low-er(P
    结果精神分裂症患者血清LPO含量和SOD活性均明显高于正常人(P<0.05,P<0.01),GPX活性明显低于正常人(P<0.01);
    Sixty-one schizophrenics were randomized into two groups blindly for comparison,the pipotiazine group(M 25, F 6;age 40± s 9 a,dosage 110± 35 mg/4wk,im for 6mo)and haloperidol group(M24,F 6;age 38± 9 a,dosage 120±28 mg/4wk im for 6mo).
    精神分裂症病人61例随机双盲分为哌泊塞嗓组(男性25例,女性6例,年龄40±s9a,每4wkim1次,平均剂量11±35mg/4wk,共6次)和氟哌啶醇组(男性24例,女性6例,年龄38±9a,每4wkim1次,平均剂量120±28mg/4wk共6次)。
    Itsuggested that the atrophy degeneration ofschizophrenic patients' brain tissues were caused bythe long - term exitement of the brain dopamine,not by antipsychotics.
    因此推测,精神分裂症病人脑组织萎缩变性是病人脑多巴胺长期亢盛导致脑组织萎缩性改变,而不是长期应用拮抗剂--抗精神病药物所致。
    METHODS: Ninety patients of schizophrenics exposed to clozapine were divided into 3 groups, each containing 30 patients.
    方法:服用氯氮平的精神分裂症病人90例,分为3组,每组30例。
    OBJECTIVE: To evaluate the influence of smoking and sex on the clinical pharmacokinetics of clozapine and its metabolite norclozapine after oral administration of fix dose (6 mg·kg -1 ) of clozapine to 30 schizophrenic patients (10 smokers, 20 non smokers).
    目的:研究30例精神分裂症患者服用固定剂量(6mg·kg-1)的氯氮平达稳态后的药动学,以及吸烟与性别对药动学的影响。
    METHODS:60 patients with schizophrenia were randomly allocated to receive 2 mg,4 mg,or 6 mg risperidone for 8 weeks.
    方法:将60例精神分裂症住院患者随机分成2,4,6mg三组,给予利培酮口服治疗8周,开放性对照3组间的疗效、不良反应。
    METHODS:41 patients with schizophrenia were randomly divided to receive risperidone( n =21) in a dose of 4~6 mg/d for 8 weeks or chlorpromazine( n =20)in a dose of 350~600 mg/d for 8 weeks.
    方法:将精神分裂症患者41例随机分成2组,21例予利培酮4~6mg/d,po治疗,20例予氯丙嗪350~600mg/d,po治疗,8周后进行对照研究。
    This article reports on electrocardiogram(ECG) of 376 cases schizophrenia using clozapine per os. The result showed the rate of abnormal ECG is 80.0% (301 cases),the male 76.9% (220 cases)and the female 90.0% (81 cases). The difference between male and female is significance(X2= 7.33, P<0.01).
    本文观察了376例口服氯氮平的精神分裂症患者的心电图改变,发现心电图异常改变的301例,发生率80.0%,其中男性286例中有220例(76.9%),女性90例中有81例(90.0%),女性心电图异常改变发生率明显高于男(x2=7.33,P<0.01);
    CONCLUSION: The genotype and allele of -1438G/A of 5-HT2A receptor gene can be the predictors to risperidone efficacy.
    结论:精神分裂症患者5-HT2A受体-1438G/A的基因型和等位基因可以作为利培酮临床疗效的预测因子。
    RESULTS:The t 1/2 of absorbtive phase, t 1/2 of clearance phase and clearance rate were 0.68,13.09,and 0.057 L/h respectively .
    结果 :精神分裂症患者吸收相半衰期为 0 .6 8h ,清除相半衰期为 13.0 9h ,清除率为 0 .0 5 7L/h。
    Method Serum IL - 6. IL - 8. IFN - r and TNF - a were measured in 39 schizophrenic patients before and after treatment with Risperdal for six weeks. Clinical features were measured with PANSS and side effect rated with TESS.
    方法对39例精神分裂症患者给予利培酮治疗6周,在治疗前后检测血清IL-6, IL-8, IFN-r和TNF-a水平,并采用PANSS量表和TESS量表评估临床症状和药物副反应。
    Method It was fixed dose from treated 13th day evening to 28th day evening in 39 inpatients with schizophrenia taking clozapine.
    方法 给39例精神分裂症病人服用氯氮平,从治疗第13天晚到第28天晚剂量固定不变。
    METHODS: Ninty-eight schizophreniform disorder and schizophrenia in and out- patients 〔M,65,F,33, age (37±s 15) a and (3.6±2.4) mo〕 received olanzapine 2.5-15 mg·d -1 in routine treatment. The EEG registrations of 98 patients before and after 8 wk treatment with olanzapine (2.5-15 mg·d -1 ) were made.
    方法 :开放性收集门诊和住院诊断为分裂样精神障碍及精神分裂症的首诊病人 98例 ,男性 65例、女性 3 3例 ,年龄为 (3 7±s1 5 )a,病程为 (3 .6±2 .4)mo,奥氮平 (2 .5~ 1 5mg·d-1)治疗前和治疗后 8wk末分别进行脑电描记术 (electroen cephalography,EEG)描记检查 ;
 

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